Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation

Sang Bum Kim; Raj K. Pandita; Ugur Eskiocak; Peter Ly; Aadil Kaisani; Rakesh Kumar; Crystal Cornelius; Woodring E. Wright; Tej K. Pandita; Jerry W. Shay

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Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation

机译：靶向Nrf2诱导DNA损伤信号转导并保护结肠上皮细胞免受电离辐射

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Nuclear factor-erythroid2-related factor 2 (Nrf2) is a key transcription regulator of antioxidant and anti-inflammation enzymes. In the cytoplasm, Nrf2 binds to its endogenous inhibitor, Kelch-like ECH-associated protein 1 (Keapl). Various endogenous or environmental oxidative stresses, such as ionizing radiation (IR), can disrupt the Nrf2-Keapl complex, which allows Nrf2 to translocate into the nucleus to induce transcription of heme oxygenase-1 (HO-1) and other cytoprotective enzymes by binding to genomic antioxidant responsive element (ARE) sequences (1). Pharmacological concentrations of a synthetic triterpenoid activate Nrf2 and induce expression of HO-1, which can suppress IR-induced oxidative stress and inflammation (2) (Fig. P1).

机译：核因子-类胡萝卜素相关因子2（Nrf2）是抗氧化剂和抗炎酶的关键转录调节因子。在细胞质中，Nrf2与其内源性抑制剂Kelch样ECH相关蛋白1（Keapl）结合。各种内源性或环境性氧化应激（例如电离辐射（IR））都可以破坏Nrf2-Keapl复合物，使Nrf2易位到细胞核中，通过结合而诱导血红素加氧酶-1（HO-1）和其他细胞保护酶的转录基因抗氧化剂反应元件（ARE）序列（1）。合成三萜类化合物的药理学浓度可以激活Nrf2并诱导HO-1的表达，从而可以抑制IR诱导的氧化应激和炎症（2）（图P1）。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第43期|17327-17327|共1页
作者
Sang Bum Kim; Raj K. Pandita; Ugur Eskiocak; Peter Ly; Aadil Kaisani; Rakesh Kumar; Crystal Cornelius; Woodring E. Wright; Tej K. Pandita; Jerry W. Shay;
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Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039;

Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039;

Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039;

Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039;

Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039;

Departments of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039;

Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039;

Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039;

Departments of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039;

Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039 Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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机译：牛磺酸通过激活Nrf2 / HO-1信号传导保护小鼠精子细胞免受电离辐射诱导的损伤
2. Exendin-4 Protects Human Retinal Pigment Epithelial Cells from H 2 O 2 -Induced Oxidative Damage via Activation of NRF2 Signaling [J] . Renzhe Cui, Lianji Tian, Di Lu, Ophthalmic Research: Journal for Research in Experimental and Clinical Ophthalmology . 2020,第4期

机译：exendin-4通过NRF2信号传导的激活保护H 2 O 2-2 O 2-2 O 2诱导的氧化损伤的人视网膜颜料上皮细胞
3. Wheat alkylresorcinols protect human retinal pigment epithelial cells against H2O2-induced oxidative damage through Akt-dependent Nrf2/HO-1 signaling [J] . Wang Ziyuan, Hao Yiming, Wang Yu, Food & Function . 2019,第5期

机译：小麦烷基丙烯醇通过AKT依赖性NRF2 / HO-1信号来保护人视网膜色素上皮细胞免受H2O2诱导的氧化损伤
4. Increasing supply of Met and Arg relative to Lys while maintaining ratios of Thr∶Phe,Lys∶Thr, Lys∶His, and Lys∶Val alters casein protein abundance via AA-induced upstream mammalian target of rapamycin signaling pathway and circadian clock of bovine mammary epithelial cells [C] . L.Y.Hu, Y.F.Chen, I.M.Cortes, The 6th International Symposium on Dairy Cow Nutrition and Milk Quality（第六届“奶牛营养与牛奶质量”国际研讨会）论文集 . -1

机译：越来越多的遇见和arg的供应，而相对于李斯，而且保持鼠窜，lys:tr，lys:his和lys:val通过AA诱导的雷帕霉素信号传导途径和牛乳清昼夜昼夜昼夜昼夜急性的哺乳动物，改变酪蛋白蛋白质丰富上皮细胞
5. ATM and the cellular response to ionizing radiation-induced DNA damage. [D] . Goodarzi, Aaron A. 2005

机译：ATM和细胞对电离辐射诱导的DNA损伤的反应。
6. PNAS Plus: Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation [O] . Sang Bum Kim, Raj K. Pandita, Ugur Eskiocak, 2012

机译：PNAS Plus：靶向Nrf2诱导DNA损伤信号转导并保护结肠上皮细胞免受电离辐射
7. Taurine Protects Mouse Spermatocytes from Ionizing Radiation-Induced Damage Through Activation of Nrf2/HO-1 Signaling [O] . Wenjun Yang, Jinfeng Huang, Bang Xiao, 2017

机译：牛磺酸通过激活Nrf2 / HO-1信号保护小鼠精母细胞免受电离辐射诱导的损伤
8. Ionizing Radiation-Induced DNA Damage and Its Repair in Human Cells [R] . Dizdaroglu, M. 1999

机译：电离辐射诱导的DNa损伤及其在人体细胞中的修复

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation

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