首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Evolutionary conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells
【24h】

Evolutionary conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells

机译:进化保守蛋白ERH控制CENP-E mRNA剪接,对于KRAS突变癌细胞的生存是必需的

获取原文
获取原文并翻译 | 示例
           

摘要

Human cancers frequently harbor mutations in the RAS family of genes. Currently, there is no therapy for treating solid tumors with RAS mutations. We focused on understanding the genetic vulnerabilities of cancer cells with RAS mutations (1, 2). We showed here that suppressing the expression of the gene enhancer of rudimentary homolog (ERH) is toxic to cancer cells with RAS mutations. Colorectal cancer patients with RAS mutations survive longer if ERH expression is low in their tumors. We identified ERH as an mRNA splicing factor that is required for the expression of several cell cycle genes, including kinesin centromere protein E (CENPE), which encodes a mitotic motor protein. Disruption of specific mRNA splicing factors could provide a therapeutic strategy for treating cancers with RAS mutations.
机译:人类癌症经常在RAS基因家族中发生突变。当前,尚无用于治疗具有RAS突变的实体瘤的疗法。我们专注于了解具有RAS突变的癌细胞的遗传脆弱性(1、2)。我们在这里表明,抑制基本同源基因(ERH)的基因增强子的表达对具有RAS突变的癌细胞具有毒性。如果ERH在肿瘤中的表达较低,则具有RAS突变的大肠癌患者存活时间更长。我们确定ERH为mRNA剪接因子,是几个细胞周期基因(包括驱动蛋白着丝粒蛋白E(CENPE))的表达所必需的,该基因编码有丝分裂运动蛋白。破坏特定的mRNA剪接因子可以为治疗RAS突变的癌症提供一种治疗策略。

著录项

  • 来源
  • 作者单位

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892,Graduate Institute of Clinical Medicine, National Taiwan University, Taipei 100, Taiwan,Far-Eastern Memorial Hospital, Taipei 220, Taiwan;

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Department of Internal Medicine,National Taiwan University Hospital and College of Medicine, Taipei 100, Taiwan;

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Proteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;

    Confocal Microscopy Core Facility, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Confocal Microscopy Core Facility, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Proteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Department of Medicine and Dan L. Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030;

    Department of Genetics, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115;

    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Department of Internal Medicine,National Taiwan University Hospital and College of Medicine, Taipei 100, Taiwan;

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号