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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila
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Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila

机译：果蝇中的长期记忆需要通过JAK / STAT途径的细胞因子信号传导

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摘要

Cytokine signaling through the JAK/STAT pathway regulates multiple cellular responses, including cell survival, differentiation, and motility. Although significant attention has been focused on the role of cytokines during inflammation and immunity, it has become clear that they are also implicated in normal brain function. However, because of the large number of different genes encoding cytokines and their receptors in mammals, the precise role of cytokines in brain physiology has been difficult to decipher. Here, we took advantage of Drosophila's being a genetically simpler model system to address the function of cytokines in memory formation. Expression analysis showed that the cytokine Upd is enriched in the Drosophila memory center, the mushroom bodies. Using tissue- and adult-specific expression of RNAi and dominant-negative proteins, we show that not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required, while being dispensable for less stable memory forms.
机译：通过JAK / STAT途径的细胞因子信号传导调节多种细胞应答，包括细胞存活，分化和运动。尽管已经将注意力集中在炎症和免疫过程中细胞因子的作用上，但是已经清楚它们也与正常的脑功能有关。然而，由于在哺乳动物中编码细胞因子及其受体的编码基因的数量众多，因此难以理解细胞因子在脑生理中的确切作用。在这里，我们利用果蝇作为遗传上更简单的模型系统来解决细胞因子在记忆形成中的功能。表达分析表明，细胞因子Upd富集在果蝇的记忆中心，即蘑菇体中。使用RNAi和显性负性蛋白质的组织和成人特异性表达，我们显示不仅蘑菇体对嗅觉厌恶的长期记忆特别需要Upd，而且Upd受体圆顶以及果蝇JAK和STAT也需要还需要同系物Hop和Stat92E，而对于不太稳定的内存形式则可以使用。

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    Tijana Copf; Valerie Goguel; Aurelie Lampin-Saint-Amaux; Niki Scaplehorn; Thomas Preat;

  • 作者单位

    Genes and Dynamics of Memory Systems, Neurobiology Unit, Ecole Superieure de Physique et de Chimie Industrielles, Centre National de la Recherche Scientifique, 75005 Paris, France,Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY 10032;

    Genes and Dynamics of Memory Systems, Neurobiology Unit, Ecole Superieure de Physique et de Chimie Industrielles, Centre National de la Recherche Scientifique, 75005 Paris, France;

    Genes and Dynamics of Memory Systems, Neurobiology Unit, Ecole Superieure de Physique et de Chimie Industrielles, Centre National de la Recherche Scientifique, 75005 Paris, France;

    Genes and Dynamics of Memory Systems, Neurobiology Unit, Ecole Superieure de Physique et de Chimie Industrielles, Centre National de la Recherche Scientifique, 75005 Paris, France;

    Genes and Dynamics of Memory Systems, Neurobiology Unit, Ecole Superieure de Physique et de Chimie Industrielles, Centre National de la Recherche Scientifique, 75005 Paris, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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