...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus
【24h】

Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus

机译:转录因子Lhx2在发育中的海马中抑制星形胶质细胞生成并促进神经发生是必要和充分的

获取原文
获取原文并翻译 | 示例
           

摘要

During the development of the verte brate CNS, progenitor cells generate neurons, the primary players in circuits, and glia, the support cells. A character istic feature of this process, common to all vertebrate species, is that the pro duction of neurons precedes that of glial cells (1). The transition from neuro genesis to gliogenesis determines the number of neurons vs. support cells that are produced in a given structure. This process is also likely to be one of the critical steps shaped by evolution to bring about the diversity of nervous systems and subsystems seen across verte brate species.
机译:在脊椎动物CNS的发育过程中,祖细胞产生神经元,即回路中的主要参与者,而神经胶质细胞则成为支持细胞。所有脊椎动物物种共有的这一过程的特征是神经元的产生先于神经胶质细胞的产生(1)。从神经发生到神经胶质发生的转变决定了在给定结构中产生的神经元与支持细胞的数量。这个过程也很可能是进化所塑造的关键步骤之一,以实现整个脊椎动物物种中神经系统和子系统的多样性。

著录项

  • 来源
  • 作者单位

    Department of Biological Sciences, Tata Institute of Fundamental Resear.cn, Mumbai 400005, India;

    Department of Biological Sciences, Tata Institute of Fundamental Resear.cn, Mumbai 400005, India;

    Department of Biological Sciences, Tata Institute of Fundamental Resear.cn, Mumbai 400005, India;

    Department of Biological Sciences, Tata Institute of Fundamental Resear.cn, Mumbai 400005, India;

    Department of Biological Sciences, Tata Institute of Fundamental Resear.cn, Mumbai 400005, India;

    Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia;

    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, CA 92697;

    Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester,MA 01605;

    Department of Biochemistry, State University of New York, Buffalo, NY 14203,Developmental Genomics Group, New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203;

    Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia;

    Department of Biological Sciences, Tata Institute of Fundamental Resear.cn, Mumbai 400005, India;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号