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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The naieve airway hyperresponsiveness of the A/J mouse is /OY-mediated
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The naieve airway hyperresponsiveness of the A/J mouse is /OY-mediated

机译：A / J小鼠的幼稚气道高反应性是/ OY介导的

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摘要

There is a wide variation among humans and mice in airway hyperresponsiveness (AHR) in the absence of allergen sensitiza-tion, i.e., naive AHR. Because mast cell (MC) activation is thought to mediate AHR in atopic asthmatic subjects, we asked whether MCs mediate naieve AHR in A/J mice. We generated an A/J congenic strain lacking c-Kit by introgression of the Wv mutation, which resulted in the elimination of MCs and the abrogation of naive AHR. Imatinib, which disrupts Kit signaling, also abrogated AHR in A/J mice. Remarkably, introduction of the Vga9 Mitf mutation into the A/J background resulted in the ablation of MCs but did not ameliorate AHR. These results indicate that c-Kit is required for
机译：在没有过敏原致敏的情况下，人和小鼠在气道高反应性（AHR）之间存在很大差异，即天真AHR。由于肥大细胞（MC）的激活被认为可以介导特应性哮喘受试者的AHR，因此我们询问MC是否介导A / J小鼠幼稚的AHR。我们通过渗入Wv突变产生了一个缺少c-Kit的A / J同系菌株，这导致MC的消除和幼稚AHR的废除。干扰Kit信号传导的伊马替尼也废除了A / J小鼠的AHR。值得注意的是，将Vga9 Mitf突变引入A / J背景导致MC消融，但并未改善AHR。这些结果表明，需要使用c-Kit

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  • 作者

    Emily Cozzi; Kate G. Ackerman; Anders Lundequist; Jeffrey M. Drazen; Joshua A. Boyce; David R. Beier;

  • 作者单位

    Division of Genetics,Children's Hospital Boston, Boston, MA 02115;

    Division of Genetics,Children's Hospital Boston, Boston, MA 02115 Division of Emergency Medicine, Children's Hospital Boston, Boston, MA 02115;

    Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School,Boston, MA 02115;

    Department of Environmental Health, Harvard School of Public Health, Boston,MA 02115;

    Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School,Boston, MA 02115 Department of Pediatrics, Harvard Medical School,Boston, MA 02115 Partners Asthma Center, Boston, MA 02115;

    Division of Genetics,Children's Hospital Boston, Boston, MA 02115;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    development of ahr in an mc-independent fashion.;

    机译：以独立于mc的方式开发ahr。;

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