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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Oxytocin receptor gene (OXTR) is related to psychological resources
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Oxytocin receptor gene (OXTR) is related to psychological resources

机译:催产素受体基因(OXTR)与心理资源有关

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Psychological resources—optimism, mastery, and self-esteem—buffer the deleterious effects of stress and are predictors of neurophysiolog-ical and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this her-itability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. 0X777 was also associated with depressive symptomatology. Mediation analysis indicates that the effects of 0X77? on depressive symptoms may be largely mediated by the influence of 0X77? on psychological resources.
机译:心理资源(乐观,精通和自尊)可缓解压力的有害影响,并且是神经生理和心理健康相关结果的预测指标。这些资源已被证明具有很高的遗传力,但是遗传性的遗传基础仍然未知。在这里,我们报告催产素受体(OXTR)SNP rs53576和心理资源之间的联系,这样相对于G / G纯合子,“ A”等位基因的携带者的乐观,精通和自尊水平较低。 0X777也与抑郁症状有关。中介分析表明0X77的影响?抑郁症状可能主要是由0X77的影响介导的?在心理资源上。

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