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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Profile of Michael Grunstein
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Profile of Michael Grunstein

机译：Michael Grunstein的个人资料

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In 2001, half a decade after researchers announced the arrival of Dolly, the first mammal cloned from an adult somatic stem cell, scientists in the private sector decided to clone a pet cat. A couple of years later the enterprise went commercial, and eager pet owners lined up for the service. However, disappointment inevitably ensued: although the clones were genetically identical to the original pets, cloned cats often looked and acted nothing like their predecessors. Michael Grunstein, were he so inclined, might have said, "I told you so." Grunstein, a distinguished professor of biological chemistry at the University of California, Los Angeles (UCLA), has devoted a lifetime of research to exploring how identical genes can be expressed differently to create unique individuals. Elected to the National Academy of Sciences in 2008, Grunstein's findings have unraveled the secrets behind the subtle interplay among genes, proteins, enzymes, and chemical markers that determines how genes and gene components are read, expressed, transferred, and copied. These secrets were discovered not by working with people-or even cats-but with yeast.
机译：2001年，在研究人员宣布第一个从成体体干细胞克隆的哺乳动物多莉（Dolly）到来的五年后，私营部门的科学家决定克隆一只宠物猫。几年后，该企业开始商业化，并渴望有宠物的主人排队等候这项服务。但是，不可避免地会产生失望：尽管这些克隆在基因上与原始宠物完全相同，但是克隆的猫通常看上去和行为都不像它们的前任。迈克尔·格伦斯坦（Michael Grunstein）可能会说：“我告诉过你。”加利福尼亚大学洛杉矶分校（UCLA）生物化学的杰出教授格伦斯坦（Grunstein）致力于研究一生，以探索如何相同地表达不同的基因来创造独特的个体。 Grunstein于2008年当选为美国国家科学院院士时，其发现揭示了基因，蛋白质，酶和化学标记之间的微妙相互作用背后的秘密，这些相互作用决定了如何读取，表达，转移和复制基因和基因成分。这些秘密不是通过与人甚至猫一起工作而发现的，而是与酵母一起发现的。

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