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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Common oxytocin receptor gene (0XTR) polymorphism and social support interact to reduce stress in humans
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Common oxytocin receptor gene (0XTR) polymorphism and social support interact to reduce stress in humans

机译:常见的催产素受体基因(0XTR)多态性与社会支持相互作用以减轻人类的压力

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摘要

The neuropeptide oxytocin has played an essential role in the regulation of social behavior and attachment throughout mammalian evolution. Because recent studies in humans have shown that oxytocin administration reduces stress responses and increases prosocial behavior, we investigated whether a common single nucleotide polymorphism (rs53576) in the oxytocin receptor gene (0XTR) might interact with stress-protective effects of social support. Salivary cortisol samples and subjective stress ratings were obtained from 194 healthy male participants before, during, and after a standardized psychosocial laboratory stress procedure. Participants were randomly assigned either to prepare alone or to receive social support from their female partner or close female friend while preparing for the stressful task. Differential stress responses between the genotype groups were observed depending on the presence or absence of social support. Only individuals with one or two copies of the G allele of rs53576 showed lower cortisol responses to stress after social support, compared with individuals with the same genotype receiving no social support. These results indicate that genetic variation of the oxytocin system modulates the effectiveness of positive social interaction as a protective buffer against a stressful experience.
机译:在整个哺乳动物进化过程中,神经肽催产素在调节社会行为和依恋方面起着至关重要的作用。因为最近在人体中的研究表明,催产素给药可以减少应激反应并增加亲社会行为,所以我们调查了催产素受体基因(0XTR)中常见的单核苷酸多态性(rs53576)是否可能与社会支持的应激保护作用相互作用。在标准化的社会心理实验室压力程序之前,之中和之后,从194名健康男性参与者中获得唾液皮质醇样品和主观压力等级。参加者被随机分配,以准备压力大的任务时独自准备或接受其女性伴侣或密友的社会支持。根据社会支持的存在与否,观察到基因型组之间的差异性应激反应。与具有相同基因型的个体没有社会支持的个体相比,只有具有一或两个rs53576 G等位基因拷贝的个体对社会支持后的应激表现出较低的皮质醇响应。这些结果表明催产素系统的遗传变异调节积极的社会互动作为抵抗压力经历的保护性缓冲的有效性。

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    Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, D-79104 Freiburg, Germany contributed equally to this work;

    Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, D-79104 Freiburg, Germany contributed equally to this work;

    Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, D-79104 Freiburg, Germany contributed equally to this work;

    Department of Psychology, National University of Singapore, Singapore 117570;

    Department of Psychology, National University of Singapore, Singapore 117570 Department of Psychology, Hebrew University of Jerusalem, Jerusalem 91905, Israel;

    Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, D-79104 Freiburg, Germany contributed equally to this work Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, D-79106 Freiburg, Germany contributed equally to this work;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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