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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Systemically dispersed innate IL-13-expressing cells in type 2 immunity
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Systemically dispersed innate IL-13-expressing cells in type 2 immunity

机译:系统分散的先天性IL-13表达细胞处于2型免疫

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摘要

Type 2 immunity is a stereotyped host response to allergens and parasitic helminths that is sustained in large part by the cytokines IL-4 and IL-13. Recent advances have called attention to the contributions by innate cells in initiating adaptive immunity, including a novel lineage-negative population of cells that secretes IL-13 and IL-5 in response to the epithelial cytokines IL-25 and IL-33. Here, we use IL-4 and IL-13 reporter mice to track lineage-negative innate cells that arise during type 2 immunity or in response to IL-25 and IL-33 in vivo. Unexpectedly, lineage-negative IL-25 (and IL-33) responsive cells are widely distributed in tissues of the mouse and are particularly prevalent in mesenteric lymph nodes, spleen, and liver. These cells expand robustly in response to exogenous IL-25 or IL-33 and after infection with the helminth Nippostrongylus brasi-liensis, and they are the major innate IL-13-expressing cells under these conditions. Activation of these cells using IL-25 is sufficient for worm clearance, even in the absence of adaptive immunity. Widely dispersed innate type 2 helper cells, which we designate Ih2 cells, play an integral role in type 2 immune responses.
机译:2型免疫是对过敏原和寄生虫的定型宿主反应,这种反应在很大程度上由细胞因子IL-4和IL-13维持。最近的进展已经引起人们对先天细胞在启动适应性免疫中的作用的关注,包括对上皮细胞因子IL-25和IL-33有反应的分泌IL-13和IL-5的新型细胞系阴性细胞。在这里,我们使用IL-4和IL-13报告基因小鼠追踪在2型免疫或体内对IL-25和IL-33的应答过程中出现的沿袭阴性先天细胞。出乎意料的是,沿袭阴性的IL-25(和IL-33)反应性细胞广泛分布在小鼠组织中,尤其在肠系膜淋巴结,脾脏和肝脏中普遍存在。这些细胞响应外源IL-25或IL-33以及在感染了蠕虫巴西夜蛾后强劲繁殖,并且在这些条件下它们是主要的先天IL-13表达细胞。即使没有适应性免疫,使用IL-25激活这些细胞也足以清除蠕虫。广泛分布的2型先天辅助细胞(我们称为Ih2细胞)在2型免疫应答中起着不可或缺的作用。

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  • 作者单位

    Howard Hughes Medical Institute, Departments of University of California, San Francisco, CA 94143-0795 Medicine University of California, San Francisco, CA 94143-0795;

    rnHoward Hughes Medical Institute, Departments of University of California, San Francisco, CA 94143-0795 Microbiology and Immunology, University of California, San Francisco, CA 94143-0795;

    rnHoward Hughes Medical Institute, Departments of University of California, San Francisco, CA 94143-0795 Microbiology and Immunology, University of California, San Francisco, CA 94143-0795;

    rnHoward Hughes Medical Institute, Departments of University of California, San Francisco, CA 94143-0795 Microbiology and Immunology, University of California, San Francisco, CA 94143-0795;

    rnLung Biology Center, University of California, San Francisco, CA 94143-0795;

    rnMedicine University of California, San Francisco, CA 94143-0795 Lung Biology Center, University of California, San Francisco, CA 94143-0795;

    rnHoward Hughes Medical Institute, Departments of University of California, San Francisco, CA 94143-0795 Medicine University of California, San Francisco, CA 94143-0795 Microbiology and Immunology, University of California, San Francisco, CA 94143-0795;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    helminth infection; IL-25; IL-33; nippostrongylus brasiliensis;

    机译:蠕虫感染25;IL-33;巴西夜蛾;

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