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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Understanding phase behavior of plant cell cortex microtubule organization
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Understanding phase behavior of plant cell cortex microtubule organization

机译：了解植物细胞皮层微管组织的相行为

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摘要

Plant microtubules are found to be strongly associated with the cell cortex and to experience polymerization/depolymerization processes that are responsible for the organization of microtubule cortical array. Here we propose a minimal model that incorporates the basic assembly dynamics and intermicrotubule interaction to understand the unexplored phase behavior of such a system. Through kinetic Monte Carlo simulations and theoretical calculations, we show that the self-organized patterns of plant cell cortical microtubules can be regulated by controlling single microtubule assembly dynamics. Biologically, this means that the structural reorganization can be regulated by microtubule-associated proteins via changing microtubule dynamic instability parameters, such as the microtubule plus-end growing rate, GTP-tubulin hydrolysis rate, etc. Such regulation is indirectly confirmed by various in vivo experiments. For the physical aspects, we not only construct the phase diagram that determines under what parameters ordered microtubule arrays form, but also predict that the essentially different ordered structures may appear through continuous and discontinuous transitions. The present study will play a central role in our understanding of the basic mechanism of plant cell noncen-trosomal microtubule arrays.
机译：发现植物微管与细胞皮层密切相关，并经历负责微管皮层阵列组织的聚合/解聚过程。在这里，我们提出了一个最小的模型，该模型结合了基本的装配动力学和微管间的相互作用，以了解这种系统的未探索相行为。通过动力学蒙特卡洛模拟和理论计算，我们表明，可以通过控制单个微管装配动力学来调节植物细胞皮质微管的自组织模式。从生物学上讲，这意味着微管相关蛋白可以通过改变微管的动态不稳定性参数（例如微管正端生长速率，GTP-微管蛋白水解速率等）来调节结构重组。这种调节可以通过各种体内间接证实实验。对于物理方面，我们不仅构造了确定有序微管阵列在什么参数下形成的相图，而且还预测了本质上不同的有序结构可能通过连续和不连续的转变而出现。本研究将在我们理解植物细胞非中心微管阵列的基本机制中发挥中心作用。

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