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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Immunodominant T-cell responses to dengue virus NS3 are associated with DHF
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Immunodominant T-cell responses to dengue virus NS3 are associated with DHF

机译：对登革热病毒NS3的免疫性T细胞反应与DHF相关

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摘要

Dengue infections are increasing at an alarming rate in many tropical and subtropical countries, where epidemics can put health care systems under extreme pressure. The more severe infections lead to dengue hemorrhagic fever (DHF), which can be life threatening. A variety of viral and host factors have been associated with the severity of dengue infections. Because secondary dengue infection is more commonly associated with DHF than primary infections, the acquired immune response to dengue, both B cells and T cells have been implicated. In this study, we set out to study T-cell responses across the entire dengue virus proteome and to see whether these were related to disease severity in a cohort of dengue-infected children from Thailand. Robust responses were observed in most infected individuals against most viral proteins. Responses to NS3 were the most frequent and there was a very strong association between the magnitude of the response and disease severity. Furthermore, in DHF, cytokine-high CD107a-negative cells predominated.
机译：在许多热带和亚热带国家，登革热感染正以惊人的速度增长，在这些国家，流行病可能使医疗保健系统承受极大的压力。更严重的感染会导致登革出血热（DHF），可能危及生命。登革热感染的严重程度与多种病毒和宿主因素有关。由于继发登革热感染比原发感染更常与DHF相关，因此已经暗示了对登革热，B细胞和T细胞的后天免疫反应。在这项研究中，我们着手研究整个登革热病毒蛋白质组中的T细胞反应，并观察这些反应是否与来自泰国的一群登革热感染儿童的疾病严重程度有关。在大多数感染的个体中，观察到针对大多数病毒蛋白的强大反应。对NS3的反应最为频繁，并且反应的幅度与疾病的严重程度之间存在非常密切的关联。此外，在DHF中，高细胞因子CD107a阴性细胞占主导地位。

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  • 作者

    Thaneeya Duangchinda; Wanwisa Dejnirattisai; Sirijit Vasanawathana; Wannee Limpitikul; Nattaya Tangthawornchaikul; Prida Malasit; Juthathip Mongkolsapaya; Gavin Screaton;

  • 作者单位

    Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W120 0NN, United Kingdom Medical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani 12120, Thailand;

    rnDivision of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W120 0NN, United Kingdom;

    rnPediatric Department, Khoh Kaen Hospital, Ministry of Public Health, Khonkaen 40000, Thailand;

    Pediatric Department, Songkhla Hospital, Ministry of Public Health, Songkhla 90100, Thailand;

    rnMedical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani 12120, Thailand;

    rnMedical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani 12120, Thailand Medical Molecular Biology Unit Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand;

    rnDivision of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W120 0NN, United Kingdom Medical Molecular Biology Unit Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand;

    rnDivision of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W120 0NN, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    flavivirus; immunopathogenesis; cytokine;

    机译：黄病毒免疫发病机制细胞因子;

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