...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Longitudinally mapping the influence of sex and androgen signaling on the dynamics of human cortical maturation in adolescence
【24h】

Longitudinally mapping the influence of sex and androgen signaling on the dynamics of human cortical maturation in adolescence

机译：纵向绘制性别和雄激素信号对青春期人类皮质成熟动力学的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Humans have systematic sex differences in brain-related behavior, cognition, and pattern of mental illness risk. Many of these differences emerge during adolescence, a developmental period of intense neurostructural and endocrine change. Here, by creating "movies" of sexually dimorphic brain development using longitudinal in vivo structural neuroimaging, we show regionally specific sex differences in development of the cerebral cortex during adolescence. Within cortical subsystems known to underpin domains of cognitive behavioral sex difference, structural change is faster in the sex that tends to perform less well within the domain in question. By stratifying participants through molecular analysis of the androgen receptor gene, we show that possession of an allele conferring more efficient functioning of this sex steroid receptor is associated with "masculinization" of adolescent cortical maturation. Our findings extend models first established in rodents, and suggest that in humans too, sex and sex steroids shape brain development in a spatiotemporally specific manner, within neural systems known to underpin sexually dimorphic behaviors.
机译：人类在大脑相关行为，认知和精神疾病风险模式方面存在系统的性别差异。这些差异中有许多在青春期期间出现，青春期是强烈的神经结构和内分泌变化的发育时期。在这里，通过使用纵向体内结构神经成像创建性双态性大脑发育的“电影”，我们在青春期大脑皮层的发育过程中显示了区域特定的性别差异。在已知支持认知行为性别差异域的皮质子系统中，性别的结构变化较快，而在该域内表现较差。通过对雄激素受体基因进行分子分析对参与者进行分层，我们表明拥有赋予该性类固醇受体更有效功能的等位基因与青少年皮质成熟的“男性化”有关。我们的发现扩展了最初在啮齿动物中建立的模型，并表明在人类中，性和性类固醇也以时空特定的方式影响着大脑的发育，该神经系统在已知支持性二态性行为的神经系统中。

著录项

  • 来源
  • 作者

    Armin Raznahan; Yohan Lee; Reva Stidd; Robert Long; Dede Greenstein; Liv Clasen; Anjene Addington; Nitin Gogtay; Judith L. Rapoport; Jay N. Giedd;

  • 作者单位

    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, London SE5 8A8, United Kingdom;

    rnChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

    rnChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

    rnChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

    rnChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

    rnChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

    rnChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

    rnChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

    rnChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

    rnChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    sex differences; brain; cortex; development; androgen receptor;

    机译：性别差异;脑;皮质发展雄激素受体;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号