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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >How to separate entangled sisters: Interplay between condensin and decatenase
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How to separate entangled sisters: Interplay between condensin and decatenase

机译：如何分离纠缠的姐妹：凝缩蛋白和脱羧酶之间的相互作用

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摘要

Chromosomes are highly orga nized in the cell, yet they un dergo dynamic conformational changes throughout the cell cy cle. Such conformational changes become crucial, particularly when duplicated chromosomes (sister chromatids) separate from each other before cell division. From a mechanistic point of view, two funda mental processes must operate for suc cessful separation of chromosomes. One is protein-mediated packaging of the DNAs to make duplicated chromosomes com pact (i.e., condensation), and the other is complete removal of entanglement be tween sister DNAs created in the process of DNA replication (i.e., decatenation). Although it has long been suspected that the two processes must be coordinated with each other, direct evidence for this idea remains scarce. A pair of papers published in PNAS now reports a comple mentary set of evidence for the physical and functional interactions between the major players responsible for condensa tion and decatenation (1, 2).
机译：染色体在细胞中高度组织化，但它们在整个细胞周期内都受到动态构象变化的影响。这种构象变化变得至关重要，特别是当重复的染色体（姐妹染色单体）在细胞分裂之前彼此分离时。从机理的角度来看，必须成功进行两个基本过程才能成功分离染色体。一种是蛋白质介导的DNA包装，以使复制的染色体紧凑（即缩合），另一种是完全消除在DNA复制过程中产生的姐妹DNA之间的缠结（即脱级）。尽管长期以来人们一直怀疑这两个过程必须相互协调，但是仍然缺乏这种想法的直接证据。现在，在PNAS上发表的两篇论文报道了负责凝结和脱级的主要参与者之间的物理和功能相互作用的补充证据（1、2）。

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