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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Heritability of reproductive fitness traits in a human population
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Heritability of reproductive fitness traits in a human population

机译：人群中生殖健康性状的遗传力

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摘要

The genetic basis of fitness traits has been studied widely in animals, yet the contribution of genetic variation to these traits in humans is controversial. In particular, it is difficult to disentangle genetic versus environmental effects on fertility, because of within-family correlations of sociocultural, economic, and other non-genetic factors that influence family sizes. In this study, we investigated the genetic architecture of reproductive fitness traits in a fertile human population whose communal lifestyle assures uniform and equal access to resources. Our study revealed significant heritabilities for reproductive traits in both men and women, after accounting for common household effects shared among siblings and demographic changes in reproductive practices. Furthermore, our results indicate that both autosomal and X-linked additive and dominance variances contribute to these traits. We therefore propose that reproductive traits should be amenable to genetic mapping studies, and the results we present here will facilitate the search for the novel genes influencing natural fertility in humans.
机译：适应性状的遗传基础已经在动物中进行了广泛研究，但是遗传变异对人类这些性状的贡献尚存争议。特别是，由于影响家庭规模的社会文化，经济和其他非遗传因素的家庭内部关联，很难区分遗传对环境对生育的影响。在这项研究中，我们调查了一个富裕人群的生殖健康特征的遗传结构，这些人群的公共生活方式确保资源的均等和平等获得。我们的研究表明，在考虑了兄弟姐妹之间共同的家庭影响和生殖方式的人口变化之后，男性和女性的生殖性状具有显着的遗传力。此外，我们的结果表明，常染色体和X连锁加性和优势变异都有助于这些特征。因此，我们建议生殖性状应适合于遗传作图研究，而我们在此提出的结果将有助于寻找影响人类自然繁殖力的新基因。

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  • 作者

    Gueluem Kosova; Mark Abney; Carole Ober;

  • 作者单位

    Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL 60637 Departments of Committee on Genetics, Genomics, and Systems Biology,University of Chicago, Chicago, IL 60637;

    rnDepartments of Committee on Genetics, Genomics, and Systems Biology,University of Chicago, Chicago, IL 60637;

    rnCommittee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL 60637 Departments of Committee on Genetics, Genomics, and Systems Biology,University of Chicago, Chicago, IL 60637 Departments of Human Genetics Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    life history traits; human fertility;

    机译：生活史特征人类的生育力;

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