Structure of toroidal DNA collapsed inside the phage capsid

Amelie Leforestier; Francoise Livolant

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Structure of toroidal DNA collapsed inside the phage capsid

机译：环形DNA的结构在噬菌体衣壳内部塌陷

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The structure of DNA toroids made of individual DNA molecules of various lengths (3,000 to 55,000 bp) was studied, by using partially filled bacteriophage capsids in conjunction with cryoelectron microscopy. The tetravalent cation spermine was diffused through the capsid to condense the DNA under conditions that were chosen to produce a hexagonal packing. Our results demonstrate that the frustration arising between chirality and hexagonal packing leads to the formation of twist walls; the correlation between helices combined with their strong curvature impose variations of the DNA helical pitch.

机译：通过使用部分填充的噬菌体衣壳结合冷冻电子显微镜，研究了由各种长度（3,000至55,000 bp）的单个DNA分子组成的DNA环的结构。在选择产生六边形堆积的条件下，四价阳离子精胺通过衣壳扩散以浓缩DNA。我们的结果表明，手性和六角形堆积之间产生的挫折感导致了扭曲壁的形成。螺旋之间的相关性加上其强大的曲率会造成DNA螺旋间距的变化。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2009年第23期|9157-9162|共6页
作者
Amelie Leforestier; Francoise Livolant;
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作者单位

Laboratoire de Physique des Solides, Centre Nationale de la Recherche Scientifique, Unite Mixte de Recherche 8502, Bat 510, Universite Paris-Sud XI, Centre d'Orsay, 91405 Orsay Cedex, France;

Laboratoire de Physique des Solides, Centre Nationale de la Recherche Scientifique, Unite Mixte de Recherche 8502, Bat 510, Universite Paris-Sud XI, Centre d'Orsay, 91405 Orsay Cedex, France;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
bacteriophage capsid; DNA helical pitch; DNA correlation; DNAtoroid; cryoelectron microscopy;

机译：噬菌体衣壳DNA螺旋螺距;DNA相关性DNAtoroid;冷冻电子显微镜;

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1. Cryoelectron microscopy of λ phage DNA condensates in vitreous ice: The fine structure of DNA toroids [J] . Nicholas V. Hud, Kenneth H. Downing Proceedings of the National Academy of Sciences of the United States of America . 2001,第26期

机译：玻璃冰中λ噬菌体DNA冷凝物的低温电子显微镜：DNA环的精细结构
2. Single-molecule and FRET fluorescence correlation spectroscopy analyses of phage DNA packaging: colocalization of packaged phage T4 DNA ends within the capsid. [J] . Ray K, Ma J, Oram M, Journal of Molecular Biology . 2010,第5期

机译：噬菌体DNA包装的单分子和FRET荧光相关光谱分析：包装的噬菌体T4 DNA的共定位在衣壳内。
3. Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus [J] . Liu Wei, Cui Yanxiang, Wang Caiyan, Nature Microbiology . 2020,第10期

机译：Epstein-Barr病毒内衣壳和衣壳相关Tegument复合物的结构
4. Using DNA Knots To Assay Packing of DNA in Phage Capsids [C] . J. Arsuaga, M. Vazquez, J. Roca, Advances in Computational Methods in Sciences and Engineering 2005 vol.4A; Lecture Series on Computer and Computational Sciences; vol.4A . 2005

机译：使用DNA结测定噬菌体衣壳中DNA的堆积
5. Knots as an assay for DNA organization inside bacteriophage P4 capsids [D] . Arsuaga, Francisco Javier 2000

机译：打结作为噬菌体P4衣壳内DNA组织的检测方法
6. Structure of toroidal DNA collapsed inside the phage capsid [O] . Amélie Leforestier, Françoise Livolant 2018

机译：环形DNA的结构在噬菌体衣壳内部塌陷
7. Structure of toroidal DNA collapsed inside the phage capsid [O] . Leforestier, Amélie, Livolant, Françoise 2009

机译：环形DNA的结构在噬菌体衣壳内部塌陷

Structure of toroidal DNA collapsed inside the phage capsid

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