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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CT-X antigen expression in human breast cancer
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CT-X antigen expression in human breast cancer

机译：人乳腺癌中CT-X抗原的表达

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摘要

Cancer/testis (CT) genes are predominantly expressed in human germ line cells, but not somatic tissues, and frequently become activated in different cancer types. Several CT antigens have already proved to be useful biomarkers and are promising targets for therapeutic cancer vaccines. The aim of the present study was to investigate the expression of CT antigens in breast cancer. Using previously generated massively parallel signature sequencing (MPSS) data, together with 9 publicly available gene expression datasets, the expression pattern of CT antigens located on the X chromosome (CT-X) was interrogated. Whereas a minority of unselected breast cancers was found to contain CT-X transcripts, a significantly higher expression frequency was detected in estrogen and progesterone receptor (ER) negative breast cancer cell lines and primary breast carcinomas. A coordinated pattern of CT-X antigen expression was observed, with MAGEA and NY-ESO-1/ CTAG1B being the most prevalent antigens. Immunohistochemical staining confirmed the correlation of CT-X antigen expression and ER negativity in breast tumors and demonstrated a trend for their coexpression with basal cell markers. Because of the limited therapeutic options for ER-negative breast cancers, vaccines based on CT-X antigens might prove to be useful.
机译：癌症/睾丸（CT）基因主要在人类生殖细胞中表达，但在体细胞组织中不表达，并且经常在不同类型的癌症中被激活。几种CT抗原已被证明是有用的生物标志物，并有望成为治疗性癌症疫苗的靶标。本研究的目的是研究CT抗原在乳腺癌中的表达。使用先前生成的大规模并行签名测序（MPSS）数据，以及9个公开可用的基因表达数据集，对位于X染色体（CT-X）上的CT抗原的表达模式进行了询问。尽管发现少数未选择的乳腺癌包含CT-X转录本，但在雌激素和孕激素受体（ER）阴性乳腺癌细胞系和原发性乳腺癌中检测到明显更高的表达频率。观察到CT-X抗原表达的协调模式，其中MAGEA和NY-ESO-1 / CTAG1B是最普遍的抗原。免疫组织化学染色证实了乳腺肿瘤中CT-X抗原表达与ER阴性之间的相关性，并证明了它们与基底细胞标记物共表达的趋势。由于ER阴性乳腺癌的治疗选择有限，基于CT-X抗原的疫苗可能被证明是有用的。

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  • 作者

    Anita Grigoriadis; Otavia L. Caballero; Keith S. Hoek; Leonard da Silva; Yao-Tseng Chen; Sandra J. Shin; Achim A. Jungbluth; Lance D. Miller; David Clouston; Jonathan Cebon; Lloyd J. Old; Sunil R. Lakhani; Andrew J. G. Simpson; A. Munro Neville;

  • 作者单位

    Ludwig Institute for Cancer Research, 605 Third Avenue, New York, NY 10158;

    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021;

    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31/F2, CH-8091 Zurich, Switzerland;

    Molecular and Cellular Pathology, UQ Centre for Clinical Research and The School of Medicine, Level 6 Building 71/918, University of Queensland, The Royal Brisbane and Women's Hospital, Herston 4029, Brisbane, Queensland, Australia;

    Weiil Medical College of Cornell University, 1300 York Avenue, New York, NY 10021;

    Weiil Medical College of Cornell University, 1300 York Avenue, New York, NY 10021;

    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021;

    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Hanes Building, Winston-Salem, NC 27157;

    Austin Health and the Cancer Vaccine Laboratory at the Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg 3084, Australia;

    Austin Health and the Cancer Vaccine Laboratory at the Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg 3084, Australia;

    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021;

    Molecular and Cellular Pathology, UQ Centre for Clinical Research and The School of Medicine, Level 6 Building 71/918, University of Queensland, The Royal Brisbane and Women's Hospital, Herston 4029, Brisbane, Queensland, Australia;

    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021;

    Ludwig Institute for Cancer Research, 605 Third Avenue, New York, NY 10158;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    cancer/testis antigens; estrogen receptor; therapy;

    机译：癌症/睾丸抗原;雌激素受体治疗;

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