Cytidine deamination induced HIV-1 drug resistance

Lubbertus C. F. Mulder; Ariana Harari; Viviana Simon

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Cytidine deamination induced HIV-1 drug resistance

机译：胞苷脱氨基诱导HIV-1耐药

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The HIV-1 Vif protein is essential for overcoming the antiviral activity of DNA-editing apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 (APOBEC3) cytidine deaminases. We show that naturally occurring HIV-1 Vif point mutants with suboptimal a

机译：HIV-1 Vif蛋白对于克服DNA编辑载脂蛋白B mRNA编辑酶，催化多肽3（APOBEC3）胞苷脱氨酶的抗病毒活性至关重要。我们显示自然发生的HIV-1 Vif点突变体具有次优a

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第14期|5501-5506|共6页
作者
Lubbertus C. F. Mulder; Ariana Harari; Viviana Simon;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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hypermutation; reservoir; diversity; reverse transcription;

机译：超突变水库多样性反转录;

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专利

1. Cytidine deamination and resistance to retroviral infection: Towards a structural understanding of the APOBEC proteins [J] . Huthoff H, Malim MH Virology . 2005,第2期

机译：胞嘧啶脱氨和对逆转录病毒感染的抵抗力：对APOBEC蛋白的结构理解
2. The Transcription Elongation Complex Directs Activation-Induced Cytidine Deaminase-Mediated DNA Deamination [J] . Eva Besmer, Eleonora Market, F. Nina Papavasiliou Molecular and Cellular Biology . 2006,第11期

机译：转录延伸复合物指导激活诱导的胞苷脱氨酶介导的DNA脱氨。
3. Analysis of strand biased 'G'.C hypermutation in human immunoglobulin V(lambda) gene segments suggests that both DNA strands are targets for deamination by activation-induced cytidine deaminase. [J] . Boursier L, Su W, Spencer J Molecular Immunology . 2004,第17期

机译：人类免疫球蛋白V（λ）基因片段中链偏向'G'.C超突变的分析表明，两条DNA链都是激活诱导的胞苷脱氨酶进行脱氨的靶标。
4. Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser~(38) phosphorylation [C] . Uttiya Basu, Andrew Franklin, Bjoern Schwer Biochemical Society Symposium . 2009

机译：通过Ser〜（38）磷酸化调节B细胞中B细胞中的胞苷脱氨酶DNA脱氨基肽活性
5. DNA deamination and binding properties of wild type and HIGM2 mutants of activation induced cytidine deaminase. [D] . Mu, Yunxiang. 2012

机译：激活诱导的胞苷脱氨酶的野生型和HIGM2突变体的DNA脱氨和结合特性。
6. Cytidine deamination induced HIV-1 drug resistance [O] . Lubbertus C. F. Mulder, Ariana Harari, Viviana Simon 2008

机译：胞苷脱氨基诱导HIV-1耐药
7. Cytidine deamination induced HIV-1 drug resistance [O] . Mulder, Lubbertus C. F., Harari, Ariana, Simon, Viviana 2008

机译：胞苷脱氨基诱导HIV-1耐药

Cytidine deamination induced HIV-1 drug resistance

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