Selective targeting of ITK blocks multiple steps of HIV replication

Julie A. Readinger; Gillian M. Schiralli; Jian-Kang Jiang; Craig J. Thomas; Avery August; Andrew J. Henderson; Pamela L. Schwartzberg

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Selective targeting of ITK blocks multiple steps of HIV replication

机译：选择性靶向ITK可阻止HIV复制的多个步骤

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Treatment for HIV has relied on the use of antiretroviral agents that can be subject to the development of resistant viruses. The study of inhibitors directed against cellular proteins required for HIV replication is therefore of growing interest. Inducib

机译：艾滋病毒的治疗依靠使用抗逆转录病毒药物，这些药物可能会产生抗药性病毒。因此，针对针对HIV复制所需的细胞蛋白的抑制剂的研究日益受到关注。诱导剂

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第18期|6684-6689|共6页
作者
Julie A. Readinger; Gillian M. Schiralli; Jian-Kang Jiang; Craig J. Thomas; Avery August; Andrew J. Henderson; Pamela L. Schwartzberg;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
Tcell signaling; transcription; tyrosine kinase; viral entry kinase inhibitors;

机译：Tcell信号;转录酪氨酸激酶病毒进入激酶抑制剂;

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1. Aptamers directed to HIV-1 reverse transcriptase display greater efficacy over small hairpin RNAs targeted to viral RNA in blocking HIV-1 replication. [J] . Joshi PJ, North TW, Prasad VR Molecular therapy: the journal of the American Society of Gene Therapy . 2005,第5期

机译：针对HIV-1逆转录酶的适体在阻止HIV-1复制方面比针对病毒RNA的小发夹RNA具有更高的功效。
2. HIV-protease inhibitors block the replication of both vesicular stomatitis and influenza viruses at an early post-entry replication step. [J] . Federico M Virology . 2011,第1期

机译：HIV蛋白酶抑制剂会在进入后的早期复制阶段阻止水泡性口炎和流感病毒的复制。
3. Interferon epsilon promotes HIV restriction at multiple steps of viral replication [J] . Garcia-Minambres Albert, Eid Sahar G., Mangan Niamh E., Immunology and Cell Biology . 2017,第5期

机译：干扰素Epsilon在病毒复制的多个步骤中促进HIV限制
4. TARGET-SELECTIVE PHOTO-DEGRADATION OF HIV-1 PROTEASE AND INHIBITION OF HIV-1 REPLICATION IN LIVING CELLS BY A FULLERENE-SUGAR HYBRID [C] . Tanimoto S., Takahashi D., Toshima K. International Carbohydrate Symposium . 2013

机译：HIV-1蛋白酶的目标选择性光降解和富勒烯 - 糖杂种活细胞中HIV-1复制的抑制作用
5. Derivatives of epoxyquinoid natural products that block activation of transcription factor NF-kappaB at multiple steps. [D] . Liang, Mei-Chih. 2006

机译：环氧醌类天然产物的衍生物可在多个步骤中阻止转录因子NF-κB的活化。
6. Selective targeting of ITK blocks multiple steps of HIV replication [O] . Julie A. Readinger, Gillian M. Schiralli, Jian-Kang Jiang, 2008

机译：选择性靶向ITK可阻止HIV复制的多个步骤
7. Selective targeting of ITK blocks multiple steps of HIV replication [O] . Readinger, Julie A., Schiralli, Gillian M., Jiang, Jian-Kang, 2008

机译：选择性靶向ITK可阻止HIV复制的多个步骤

Selective targeting of ITK blocks multiple steps of HIV replication

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