Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

Klaus Hellmuth; Stefanie Grosskopf; Ching Tung Lum; Martin Wiirtele; Nadine Roeder; Jens Peter von Kries; Marta Rosario; Joerg Rademann; Walter Birchmeier

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Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

机译：通过高通量对接鉴定出蛋白质酪氨酸磷酸酶Shp2的特异性抑制剂

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The protein tyrosine phosphatase 5hp2 is a positive regulator of growth factor signaling. Gain-of-function mutations in several types of leukemia define Shp2 as a bona fide oncogene. We performed a high-throughput in silico screen for small-molecular-weig

机译：蛋白质酪氨酸磷酸酶5hp2是生长因子信号转导的正调节剂。几种类型的白血病中的功能获得性突变将Shp2定义为真正的癌基因。我们对小分子微粉进行了高通量硅胶筛选

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第20期|7275-7280|共6页
作者
Klaus Hellmuth; Stefanie Grosskopf; Ching Tung Lum; Martin Wiirtele; Nadine Roeder; Jens Peter von Kries; Marta Rosario; Joerg Rademann; Walter Birchmeier;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
chemical biology; growth factor signaling; phosphatase inhibition; virtual drug screening;

机译：化学生物学;生长因子信号;磷酸酶抑制;虚拟药物筛选;

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1. Probing the acting mode and advantages of RMC-4550 as an Src-homology 2 domain-containing protein tyrosine phosphatase (SHP2) inhibitor at molecular level through molecular docking and molecular dynamics [J] . Journal of Biomolecular Structure and Dynamics . 2020,第5a6期

机译：通过分子对接和分子动力学在分子水平下探测RMC-4550的作用模式和优点作为含SRC-同源性2结构域的蛋白酪氨酸磷酸酶（SHP2）抑制剂
2. Molecular Docking and High-Throughput Screening for Novel Inhibitors of Protein Tyrosine Phosphatase-1B [J] . Thompson N. Doman, Susan L. McGovern, Bryan J. Witherbee, Journal of Medicinal Chemistry . 2002,第11期

机译：酪氨酸磷酸酶-1B新型抑制剂的分子对接和高通量筛选
3. Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1???±) docking protein Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1???±) docking protein Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1???±) docking protein [J] . Veerle De Wever, Jens Andersen, Mhairi Nimick, Biology Open . 2012,第2期

机译：Taperin（c9orf75），一种非综合征性耳聋的突变基因，编码脊椎动物特异性的核定位蛋白磷酸酶一个α（PP1 ???±）对接蛋白Taperin（c9orf75），一种非综合征性耳聋的突变基因，编码脊椎动物的特异性核蛋白局部蛋白磷酸酶一α（PP1 ???±）对接蛋白Taperin（c9orf75），一种非综合征性耳聋的突变基因，编码脊椎动物特异性的核定位蛋白磷酸酶一α（PP1 ???±）对接蛋白。
4. Actinodaphnine and Rutacridone as New T-Cell Protein Tyrosine Phosphatase Inhibitors for Drug Development of Obesity [C] . Y Fitrianingrum, D Indarto, R Kusumawati Annual Basic Science International Conference . 2019

机译：Actinodaphnine和Rutacridone作为新的T细胞蛋白酪氨酸磷酸酶抑制剂，用于肥胖的药物发育
5. Defining the role of the shp2 protein tyrosine phosphatase in FcϵRI signaling in mast cells [D] . McPherson, Victor Allon 2008

机译：定义shp2蛋白酪氨酸磷酸酶在肥大细胞FcϵRI信号传导中的作用
6. Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking [O] . Klaus Hellmuth, Stefanie Grosskopf, Ching Tung Lum, 2008

机译：通过高通量对接鉴定出蛋白质酪氨酸磷酸酶Shp2的特异性抑制剂
7. Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking [O] . Hellmuth, Klaus, Grosskopf, Stefanie, Lum, Ching Tung, 2008

机译：通过高通量对接鉴定出蛋白质酪氨酸磷酸酶Shp2的特异性抑制剂
8. Study of Inhibitors of Neu and Related Tyrosine-Specific Protein Kinases: Implications for the Treatment of Breast Cancer [R] . Edelman, A. 1998

机译：Neu和相关酪氨酸特异性蛋白激酶抑制剂的研究：对乳腺癌治疗的启示

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

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