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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis
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Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis

机译：选择在脑膜炎奈瑟氏球菌谱系出现和毒力进化中的作用

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摘要

Neisseria meningitis is a human commensal bacterium that occasionally causes life-threatening disease. As with a number of other bacterial pathogens, meningococcal populations comprise distinct lineages, which persist over many decades and during global spread in the face of high rates of recombination. In addition, the propensity to cause invasive disease is associated with particular "hyperinvasive" lineages that coexist with less invasive lineages despite the fact that disease does not contribute to host-to-host transmission. Here, by combining a modeling approach with molecular epidemiological data from 1,108 meningococci isolated in the Czech Republic over 27 years, we show that interstrain competition, mediated by immune selection, can explain both the persistence of multiple discrete meningococcal lineages and the association of a subset of these with invasive disease. The model indicates that the combinations of allelic variants of housekeeping genes that define these lineages are associated with very small differences in transmission efficiency among hosts. These findings have general implications for the emergence of lineage structure and virulence in recombining bacterial populations.
机译：奈瑟氏菌脑膜炎是一种人类共患细菌，偶尔会导致威胁生命的疾病。与许多其他细菌性病原体一样，脑膜炎球菌种群包含不同的谱系，这些谱系在数十年之内持续存在，并且在全球传播期间面临着高重组率。另外，尽管疾病不促进宿主之间的传播，但引起侵袭性疾病的倾向与特定的“侵袭性”谱系与侵袭性较低的谱系共存。在这里，通过将建模方法与来自捷克共和国的27年间分离的1,108例脑膜炎球菌的分子流行病学数据相结合，我们表明，通过免疫选择介导的品系间竞争可以解释多个离散脑膜炎球菌谱系的持续存在以及子集的关联其中有浸润性疾病。该模型表明，定义这些谱系的管家基因等位基因变体的组合与宿主之间传播效率的很小差异相关。这些发现对重组细菌种群中谱系结构和毒力的出现具有普遍意义。

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