A Consensus View Of Dna Binding By The C Family Of Replicative Dna Polymerases

Meindert H. Lamers; Mike ODonnell

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A Consensus View Of Dna Binding By The C Family Of Replicative Dna Polymerases

机译：复制的Dna聚合酶C家族的Dna绑定的共识视图。

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The DNA polymerases that duplicate bacterial chromosomes are members of the C family of polymerases, which shares no sequence homology with any of the other DNA polymerase families. In Gram-negative bacteria the replicative polymerase is polymerase III α-subunit (Pol III), whereas in Gram-positive bacteria the replicative polymerase is called Pol C. Even though the first C family polymerase was discovered ≈40 years ago (1), it is the last polymerase family to be studied structurally. C family polymerases are quite large multidomain proteins, larger than polymerases of other families, which may explain why structural representatives of this class have been solved only recently. In this issue of PNAS, Evans et al.

机译：复制细菌染色体的DNA聚合酶是聚合酶C家族的成员，该家族与其他任何DNA聚合酶家族都不具有序列同源性。在革兰氏阴性细菌中，复制性聚合酶是聚合酶IIIα亚基（Pol III），而在革兰氏阳性细菌中，复制性聚合酶被称为PolC。尽管大约40年前发现了第一个C族聚合酶（1），它是最后一个在结构上需要研究的聚合酶家族。 C家族聚合酶是相当大的多域蛋白，比其他家族的聚合酶要大，这可以解释为什么此类结构的代表仅在最近才得到解决。在本期PNAS中，Evans等人。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第52期|20565-20566|共2页
作者
Meindert H. Lamers; Mike ODonnell;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family [J] . Jozwiakowski Stanislaw K., Keith Brian J., Gilroy Louise, Nucleic Acids Research . 2014,第15期

机译：能够复制过去的DNA损伤的古细菌家族B DNA聚合酶变体：B家族内复制和跨病变合成聚合酶的发生
2. An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family [J] . Jozwiakowski Stanislaw K., Keith Brian J., Gilroy Louise, Nucleic Acids Research . 2014,第15期

机译：能够复制过去的DNA损伤的古细菌家族B DNA聚合酶变体：B家族内复制和跨病变合成聚合酶的发生
3. An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family [J] . Aidan J. Doherty, Bernard A. Connolly, Brian J. Keith, Nucleic acids research . 2014,第15期

机译：能够复制过去的DNA损伤的古细菌家族-B DNA聚合酶变体：B家族内复制和跨病变合成聚合酶的发生
4. Towards an understanding of protein-protein interaction network hierarchies. Analysis of DnaN (β)-binding peptide motifs in members of protein families interacting with the eubacterial processivity clamp, the β subunit of DNA Polymerase III [C] . Brian P. Dalrymple, Gene Wijffels, Kritaya Kongsuwan, Asia-Pacific Bioinformatics Conference(APBC 2003); 200302; Adelaide(AU) . 2003

机译：对蛋白质-蛋白质相互作用网络层次结构的理解。蛋白质家族成员与DNA聚合酶III的优生过程性钳位相互作用的DnaN（β）结合肽基序分析
5. Structural Studies of Y-family DNA Polymerases Eta and Kappa: Replication Through Ultraviolet-Induced and Oxidative DNA Damage [D] . Silverstein, Timothy David 2011

机译：Y家族DNA聚合酶Eta和κ的结构研究：通过紫外线诱导和氧化性DNA损伤的复制。
6. A consensus view of DNA binding by the C family of replicative DNA polymerases [O] . Meindert H. Lamers, Mike ODonnell 2008

机译：复制性DNA聚合酶C家族对DNA结合的共识
7. A consensus view of DNA binding by the C family of replicative DNA polymerases [O] . Lamers, Meindert H., O'Donnell, Mike 2008

机译：复制性DNA聚合酶C家族对DNA结合的共识

A Consensus View Of Dna Binding By The C Family Of Replicative Dna Polymerases

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