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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Retrospective and prospective responses arising in a modeled hippocampus during maze navigation by a brain-based device
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Retrospective and prospective responses arising in a modeled hippocampus during maze navigation by a brain-based device

机译：基于大脑的设备在迷宫导航过程中建模海马体中产生的回顾性和前瞻性反应

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摘要

Recent recordings of place field activity in rodent hippocampus have revealed correlates of current, recent past, and imminent future events in spatial memory tasks. To analyze these properties, we used a brain-based device, Darwin Ⅺ, that incorporated a detailed model of medial temporal structures shaped by experience-dependent synaptic activity. Darwin Ⅺ was tested on a plus maze in which it approached a goal arm from different start arms. In the task, a journey corresponded to the route from a particular starting point to a particular goal. During maze navigation, the device developed place-dependent responses in its simulated hippocampus. Journey-dependent place fields, whose activity differed in different journeys through the same maze arm, were found in the recordings of simulated CA1 neuronal units. We also found an approximately equal number of journey-independent place fields. The journey-dependent responses were either retrospective, where activity was present in the goal arm, or prospective, where activity was present in the start arm. Detailed analysis of network dynamics of the neural simulation during behavior revealed that many different neural pathways could stimulate any single CA1 unit. That analysis also revealed that place activity was driven more by hippocampal and entorhinal cortical influences than by sensory cortical input. Moreover, journey-dependent activity was driven more strongly by hippocampal influence than journey-independent activity.
机译：啮齿动物海马中场所磁场活动的最新记录揭示了空间记忆任务中当前，最近的过去和即将发生的未来事件的相关性。为了分析这些特性，我们使用了基于大脑的装置DarwinⅪ，该装置结合了由经验依赖的突触活动形成的内侧颞部结构的详细模型。达尔文（DarwinⅪ）在正迷宫中进行了测试，从不同的起始臂逼近了一个目标臂。在任务中，旅程对应于从特定起点到特定目标的路线。在迷宫导航期间，该设备在其模拟的海马体中产生了位置相关的响应。在模拟的CA1神经元单位的记录中发现了与旅程有关的场所，其活动在通过同一迷宫臂的不同旅程中有所不同。我们还发现了与旅途无关的位置字段数量大致相等。依赖于旅程的响应是回顾性的（目标活动中存在活动）或前瞻性的（起始活动中存在活动）。行为期间神经模拟的网络动力学的详细分析显示，许多不同的神经途径可以刺激任何单个CA1单元。该分析还表明，场所活动更多是由海马和内嗅皮质的影响所驱动，而不是由感觉皮质的输入所驱动。而且，与海马无关的活动比海马无关的活动受海马影响的驱动更大。

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