...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation
【24h】

Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation

机译：减数分裂重组相关的DNA合成及其对交叉和非交叉重组形成的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Meiotic recombination-related DNA synthesis (MRDS) was analyzed in Saccharomyces cerevisiae by specifically timed incorporation of thymidine analogs into chromosomes. Lengths and positions of incorporation tracts were determined relative to a known recombination hot spot along DNA, as was the timing and localization of incorporation relative to forming and formed synaptonemal complex in spread chromosomes. Distinct patterns could be specifically associated with the majority cross-over and non-cross-over recombination processes. The results obtained provide direct evidence for key aspects of current consensus recombination models, provide information regarding temporal and spatial relationships between non-cross-over formation and the synaptonemal complex, and raise the possibility that removal of RecA homolog Rad51 plays a key role in regulating onset of MRDS. Finally, classical observations on MRDS in Drosophila, mouse, and lily are readily mapped onto the findings presented here, providing further evidence for a broadly conserved meiotic recombination process.
机译：通过将胸苷类似物特别定时地掺入染色体，在酿酒酵母中分析了减数分裂重组相关的DNA合成（MRDS）。相对于沿DNA的已知重组热点确定掺入区的长度和位置，以及掺入的时间和位置相对于在扩散染色体中形成和形成的联会复合物而言。不同的模式可能与大多数交叉和非交叉重组过程特别相关。获得的结果为当前共识重组模型的关键方面提供了直接证据，提供了有关非交叉形成与突触复合体之间时空关系的信息，并提高了RecA同源物Rad51的去除在调节中起关键作用的可能性。 MRDS的发作。最后，关于果蝇，小鼠和百合中MRDS的经典观察结果很容易映射到此处介绍的发现中，从而为广泛保守的减数分裂重组过程提供了进一步的证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号