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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mutations in clusters and showers
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Mutations in clusters and showers

机译：簇和阵雨的突变

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摘要

Several years ago, mutants arising spontaneously in a mutation-reporter sequence in a mouse were noted to contain more mutants bearing two or more mutations than was predicted by the mutation frequency and the assumption of a random distribution of mutations among mutants. Many of these overloaded mutants contained two mutations that were moderately close to each other. In this issue of PNAS, Wang et al. (2) describe the results of a robust sequencing effort to examine the same mutants over many kilobases outside of the original mutation reporter, and they find that some of the mutants contain even more mutations farther out in genetic space.
机译：几年前，与突变频率和假定突变在突变体之间随机分布所预测的相比，小鼠中以突变报告序列自发产生的突变体被发现包含两个或两个以上突变的突变体。这些重载突变体中的许多突变体包含两个彼此适度接近的突变。在本期PNAS中，Wang等人。 （2）描述了在原始突变报告基因之外许多千碱基范围内检查相同突变体的强大测序工作的结果，他们发现某些突变体在遗传空间中包含的突变甚至更多。

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