...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Comparative genomics provides evidence for close evolutionary relationships between the urotensin Ⅱ and somatostatin gene families
【24h】

Comparative genomics provides evidence for close evolutionary relationships between the urotensin Ⅱ and somatostatin gene families

机译：比较基因组学提供了尿素Ⅱ与生长抑素基因家族紧密进化关系的证据

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although urotensin Ⅱ (UII) and somatostatin 1 (SS1) exhibit some structural similarities, their precursors do not show any appreciable sequence identity and, thus, it is widely accepted that the UII and SS1 genes do not derive from a common ancestral gene. The recent characterization of novel isoforms of these two peptides, namely urotensin Ⅱ-related peptide (URP) and somatostatin 2 (SS2)/cortistatin (CST), provides new opportunity to revisit the phylo-genetic relationships of UII and SS1 using a comparative genomics approach. In the present study, by radiation hybrid mapping and in silico sequence analysis, we have determined the chromosomal localization of the genes encoding UII- and somatostatin-related peptides in several vertebrate species, including human, chicken, and zebrafish. In most of the species investigated, the UII and URP genes are closely linked to the SS2/CST and SS1 genes, respectively. We also found that the UII-SS2/CST locus and the URP/SS1 locus are paralogous. Taken together, these data indicate that the UII and URP genes, on the one hand, and the SS1 and SS2/CST genes, on the other hand, arose through a segmental duplication of two ancestral genes that were already physically linked to each other. Our results also suggest that these two genes arose themselves through a tandem duplication of a single ancestral gene. It thus appears that the genes encoding UII- and somatostatin-related peptides belong to the same superfamily.
机译：尽管尿紧张素Ⅱ（UII）和生长抑素1（SS1）表现出一些结构相似性，但它们的前体没有任何明显的序列同一性，因此，UII和SS1基因并非源自共同的祖先基因，这已被广泛接受。最近对这两种肽的新同工型的表征，即尿紧张素Ⅱ相关肽（URP）和生长抑素2（SS2）/皮质抑素（CST），为使用比较基因组学重新审视UII和SS1的亲缘关系提供了新的机会。方法。在本研究中，通过辐射杂交作图和计算机序列分析，我们确定了在包括人，鸡和斑马鱼在内的几种脊椎动物中，编码UII和生长抑素相关肽的基因的染色体定位。在调查的大多数物种中，UII和URP基因分别与SS2 / CST和SS1基因紧密相连。我们还发现UII-SS2 / CST基因座和URP / SS1基因座是同源的。综上所述，这些数据表明，一方面是UII和URP基因，另一方面是SS1和SS2 / CST基因，是通过对已经彼此物理连接的两个祖先基因进行分段复制而产生的。我们的结果还表明，这两个基因是通过串联复制单个祖先基因而产生的。因此看来，编码UII和生长抑素相关肽的基因属于同一个超家族。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号