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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The partitioned Rhizobium etli genome: Genetic and metabolic redundancy in seven interacting replicons
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The partitioned Rhizobium etli genome: Genetic and metabolic redundancy in seven interacting replicons

机译：分离的根瘤菌基因组基因：七个相互作用复制子的遗传和代谢冗余

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摘要

We report the complete 6,530,228-bp genome sequence of the symbiotic nitrogen fixing bacterium Rhizobium etli. Six large plasmids comprise one-third of the total genome size. The chromosome encodes most functions necessary for cell growth, whereas few essential genes or complete metabolic pathways are located in plasmids. Chromosomal synteny is disrupted by genes related to insertion sequences, phages, plasmids, and cell-surface components. Plasmids do not show synteny, and their orthologs are mostly shared by accessory replicons of species with multipartite genomes. Some nodulation genes are predicted to be functionally related with chromosomal loci encoding for the external envelope of the bacterium. Several pieces of evidence suggest an exogenous origin for the symbiotic plasmid (p42d) and p42a. Additional putative horizontal gene transfer events might have contributed to expand the adaptive repertoire of R. etli, because they include genes involved in small molecule metabolism, transport, and transcriptional regulation. Twenty-three putative sigma factors, numerous isozymes, and paralogous families attest to the metabolic redundancy and the genomic plasticity necessary to sustain the lifestyle of R. etli in symbiosis and in the soil.
机译：我们报告了共生固氮细菌根瘤菌等完整的6,530,228-bp基因组序列。六个大质粒占总基因组大小的三分之一。染色体编码细胞生长所需的大多数功能，而质粒中几乎没有必需的基因或完整的代谢途径。染色体序列被与插入序列，噬菌体，质粒和细胞表面成分有关的基因破坏。质粒没有表现出同质性，它们的直系同源物大部分被具有多部分基因组的物种的辅助复制子共享。据预测，某些结瘤基因与编码细菌外部包膜的染色体基因座在功能上相关。一些证据表明共生质粒（p42d）和p42a的外源起源。其他假定的水平基因转移事件可能有助于扩大R. etli的适应性库，因为它们包括参与小分子代谢，转运和转录调控的基因。二十三个推定的sigma因子，众多同工酶和旁系家族证明了维持共生和土壤中R. etli生活方式的代谢冗余和基因组可塑性。

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