...

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system

【24h】

The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system

机译：ENH蛋白是神经系统正常细胞和肿瘤细胞中Id2的胞质螯合因子

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Id2 is a natural inhibitor of the basic helix-loop-helix transcription factors and the retinoblastoma tumor suppressor protein. Active Id2 prevents differentiation and promotes cell-cycle progression and tumorigenesis in the nervous system. A key event that regulates Id2 activity during differentiation is translocation from the nucleus to the cytoplasm. Here we show that the actin-associated protein enigma homolog (ENH) is a cytoplasmic retention factor for Id2. ENH contains three LIM domains, which bind to the helix-loop-helix domain of Id proteins in vitro and in vivo. ENH is up-regulated during neural differentiation, and its ectopic expression in neuroblastoma cells leads to translocation of Id2 from the nucleus to the cytoplasm, with consequent inactivation of transcriptional and cell-cycle-promoting functions of IQ. Conversely, silencing of ENH by RNA interference prevents cytoplasmic relocation of Id2 in neuroblastoma cells differentiated with retinoic acid. Finally, the differentiated neural crest-derived tumor ganglioneuroblastoma coexpresses Id2 and ENH in the cytoplasm of ganglionic cells. These data indicate that ENH contributes to differentiation of the nervous system through cytoplasmic sequestration of Id2. They also suggest that ENH is a restraining factor of the oncogenic activity of Id proteins in neural tumors.

机译：Id2是基本螺旋-环-螺旋转录因子和成视网膜细胞瘤肿瘤抑制蛋白的天然抑制剂。活性Id2可防止分化并促进神经系统的细胞周期进程和肿瘤发生。在分化过程中调节Id2活性的关键事件是从细胞核到细胞质的转运。在这里，我们显示肌动蛋白相关的蛋白质谜同源（ENH）是Id2的细胞质保留因子。 ENH包含三个LIM域，它们在体外和体内均与ID蛋白的螺旋-环-螺旋结构域结合。 ENH在神经分化过程中被上调，其在神经母细胞瘤细胞中的异位表达导致Id2从细胞核转移到细胞质，从而使IQ的转录和细胞周期促进功能失活。相反，通过RNA干扰使ENH沉默可防止Id2在视黄酸分化的成神经细胞瘤细胞中发生胞质重定位。最后，分化的神经c衍生的神经节神经母细胞瘤在神经节细胞的细胞质中共表达Id2和ENH。这些数据表明，ENH通过Id2的胞质隔离促进神经系统的分化。他们还表明，ENH是Id蛋白在神经肿瘤中致癌活性的抑制因子。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2006年第13期|p. 4976-4981|共6页
作者
Lasorella A; Iavarone A;
展开▼
作者单位

Columbia Univ, Med Ctr, Inst Canc Genet, Dept Pathol Pediat & Neurol, New York, NY 10032 USA;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
differentiation; enigma homolog; Id proteins; neural cancer; LOOP-HELIX PROTEINS; LIM DOMAIN PROTEIN; HUMAN NEUROBLASTOMA; TRANSCRIPTION FACTORS; DIFFERENTIATION; GROWTH; GENE; CANCER; CYCLE; PDZ;

机译：分化;enigma同源物;Id蛋白;神经癌;LOOP-HELIX蛋白;Lim域蛋白;人神经母细胞瘤;转录因子;分化;生长;基因;基因;癌症;循环;PDZ;

相似文献

外文文献
中文文献
专利

1. Scientific Opinion on the substantiation of health claims related to riboflavin (vitamin B2) and contribution to normal energy‐yielding metabolism (ID 29, 35, 36, 42), contribution to normal metabolism of iron (ID 30, 37), maintenance of normal skin and mucous membranes (ID 31, 33), contribution to normal psychological functions (ID 32), maintenance of normal bone (ID 33), maintenance of normal teeth (ID 33), maintenance of normal hair (ID 33), maintenance of normal nails (ID 33), maintenance of normal vision (ID 39), maintenance of normal red blood cells (ID 40), reduction of tiredness and fatigue (ID 41), protection of DNA, proteins and lipids from oxidative damage (ID 207), and maintenance of the normal function of the nervous system (ID 213) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2010,第10期

机译：关于证实与核黄素（维生素B2）有关的健康主张以及对正常能量产生代谢的贡献（ID 29、35、36、42），对铁正常代谢的贡献（ID 30、37），维持正常的科学见解皮肤和粘膜（ID 31、33），对正常心理功能的贡献（ID 32），维持正常骨骼（ID 33），维持正常牙齿（ID 33），维持正常头发（ID 33），维持正常指甲（ID 33），维持正常视力（ID 39），维持正常红细胞（ID 40），减轻疲劳和疲劳（ID 41），保护DNA，蛋白质和脂质免受氧化损伤（ID 207）），并根据第（EC）1924/2006号法规第13（1）条维护神经系统的正常功能（ID 213）
2. Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins [J] . Krakowski AR, Laboureau J, Mauviel A, Proceedings of the National Academy of Sciences of the United States of America . 2005,第35期

机译：正常组织和非恶性细胞中的细胞质SnoN通过隔离Smad蛋白来拮抗TGF-β信号传导
3. Nuclear Translocation of Hand-1 Acts as a Molecular Switch to Regulate Vascular Radiosensitivity in Medulloblastoma Tumors: The Protein uPAR Is a Cytoplasmic Sequestration Factor for Hand-1 [J] . Asuthkar Swapna, Gogineni Venkateswara Rao, Rao Jasti S., Molecular cancer therapeutics . 2014,第5期

机译：Hand-1的核易位充当调节髓母细胞瘤肿瘤中血管放射敏感性的分子开关：uPAR蛋白是Hand-1的细胞质螯合因子。
4. Markedly Reduced Evolutionary Rates of Transcription Factors and Cytoplasmic Ribosomal RNAs and Proteins in Higher Vertebrates and Their Evolutionary Implications [C] . Daisuke Hoshiyama, Kei-ichi Kuma, Takashi Miyata International Workshop on Bioinformatics and Systems Biology . 2004

机译：显着降低了较高脊椎动物中的转录因子和细胞质核糖核酸RNA和蛋白质的进化率及其进化意义
5. Study of factors related to childhood leukemia and to central nervous system tumors in California [D] . Oksuzyan, Sona 2013

机译：在加州研究与儿童白血病和中枢神经系统肿瘤相关的因素
6. The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system [O] . Anna Lasorella, Antonio Iavarone 2006

机译：ENH蛋白是神经系统正常细胞和肿瘤细胞中Id2的胞质螯合因子
7. The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system [O] . Lasorella, Anna, Iavarone, Antonio 2006

机译：ENH蛋白是神经系统正常细胞和肿瘤细胞中Id2的胞质螯合因子
8. Isolation of Proteins Interacting With the Cyclin D1-CDK6 Complex From Normal and Tumorigenic Human Breast Cells Using a Novel Yeast Three-Hybrid System [R] . Nichols, M. A. , Xiong, Y. 1999

机译：使用新型酵母三杂交系统分离与正常和致瘤人乳腺细胞中的细胞周期蛋白D1-CDK6复合物相互作用的蛋白质

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

客服微信
服务号