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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The real estate of cardiac signaling: Location, location, location
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The real estate of cardiac signaling: Location, location, location

机译：心脏信号传导的位置：位置，位置，位置

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摘要

Determining how cells distinguish between adaptive and maladaptive signals when they appear to share the same molecular pathways has been a vexing biological problem. The ability to identify distinctive features of a pathophysiologi-cal response compared with a physiological response would allow for the rational design of approaches to eliminate or diminish undesirable consequences of pathophysiological responses while preserving the beneficial effects of physiological signals. These issues are especially pertinent in the heart and in understanding the development of heart failure, for which > 500,000 new cases are diagnosed in the United States each year. Major factors contributing to worsening heart failure include a number of compensatory neurohormonal signals intended to counteract decreased cardiac output, such as hyperadrenergic stimulation. In a recent issue of PNAS, Balijepalli et al. provide new insight into how adrenergic signaling pathways are organized in the heart.
机译：当细胞似乎共享相同的分子途径时，如何确定细胞如何区分适应性信号和适应不良信号一直是一个棘手的生物学问题。与生理反应相比，识别病理生理反应的独特特征的能力将允许合理设计消除或减少病理生理反应的不良后果的方法，同时保留生理信号的有益作用。这些问题在心脏和理解心力衰竭的发展中尤为相关，在美国每年诊断出超过500,000例新病例。导致心力衰竭恶化的主要因素包括许多旨在抵消心输出量减少的代偿性神经激素信号，例如高肾上腺素能刺激。在最近一期的PNAS中，Balijepalli等人。提供有关肾上腺素信号传导途径如何在心脏中组织的新见解。

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