...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films
【24h】

Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films

机译：控制层间扩散，以实现从一层到一层的薄膜持续的多试剂递送

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We present the fabrication of conformal, hydrolytically degradable thin films capable of administering sustained, multiagent release profiles. Films are constructed one molecular layer at a time by using the layer-by-layer, directed-deposition technique; the subsequent hydrolytic surface erosion of these systems results in the release of incorporated materials in a sequence that reflects their relative positions in the film. The position of each species is determined by its ability to diffuse throughout the film architecture, and, as such, the major focus of this work is to define strategies that physically block interlayer diffusion during assembly to create multicomponent, stratified films. By using a series of radiolabeled polyelectrolytes as experimental probes, we show that covalently crosslinked barriers can effectively block interlayer diffusion, leading to compartmentalized structures, although even very large numbers of ionically crosslinked (degradable or nondegradable) barrier layers cannot block interlayer diffusion. By using these principles, we designed degradable films capable of extended release as well as both parallel and serial multiagent release. The ability to fabricate multicomponent thin films with nanoscale resolution may lead to a host of new materials and applications.
机译：我们介绍了保形的，可水解降解的薄膜的制造，该薄膜能够管理持续的多试剂释放曲线。通过使用逐层定向沉积技术，可一次将一个分子层构建成一层膜；这些系统随后发生的水解表面侵蚀导致所结合材料的释放顺序能够反映出它们在薄膜中的相对位置。每个种类的位置取决于其在整个膜结构中的扩散能力，因此，这项工作的主要重点是确定在组装过程中物理阻止层间扩散的策略，以形成多层的多层膜。通过使用一系列放射性标记的聚电解质作为实验探针，我们表明，即使即使大量的离子交联（可降解或不可降解）阻挡层也无法阻挡层间扩散，共价交联的阻挡层也可以有效地阻挡层间扩散，从而形成分隔的结构。通过使用这些原理，我们设计了可降解的薄膜，该薄膜能够延长释放以及并行和串行多代理释放。制造具有纳米级分辨率的多组分薄膜的能力可能会导致许多新材料和应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号