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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Topological units of environmental signal processing in the transcriptional regulatory network of Escherichia coli
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Topological units of environmental signal processing in the transcriptional regulatory network of Escherichia coli

机译：大肠杆菌转录调控网络中环境信号处理的拓扑单元

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摘要

Recent evidence indicates that potential interactions within metabolic, protein-protein interaction, and transcriptional regulatory networks are used differentially according to the environmental conditions in which a cell exists. However, the topological units underlying such differential utilization are not understood. Here we use the transcriptional regulatory network of Escherichia coli to identify such units, called origons, representing regulatory subnetworks that originate at a distinct class of sensor transcription factors. Using microarray data, we find that specific environmental signals affect mRNA expression levels significantly only within the origons responsible for their detection and processing. We also show that small regulatory interaction patterns, called subgraphs and motifs, occupy distinct positions in and between origons, offering insights into their dynamical role in information processing. The identified features are likely to represent a general framework for environmental signal processing in prokaryotes.
机译：最近的证据表明，根据细胞所处的环境条件，代谢，蛋白质-蛋白质相互作用和转录调节网络内的潜在相互作用被不同地使用。但是，不了解这种差异利用的拓扑单元。在这里，我们使用大肠杆菌的转录调控网络来识别这种称为origons的单位，这些单位代表起源于不同类别的传感器转录因子的调控子网。使用微阵列数据，我们发现特定的环境信号仅在负责其检测和处理的折角内显着影响mRNA表达水平。我们还表明，称为子图和主题的小型监管互动模式在折纸折纸之间或折纸折纸之间占据不同的位置，从而洞察了它们在信息处理中的动态作用。所识别的特征可能代表原核生物中环境信号处理的一般框架。

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