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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The evolution of vertebrate Toll-like receptors
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The evolution of vertebrate Toll-like receptors

机译：脊椎动物Toll样受体的进化

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The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure for recognition of and response to pathogen-associated molecular patterns has maintained a largely unchanging TLR recognition in all vertebrates. There are six major families of vertebrate TLRs. This repertoire is distinct from that of invertebrates. TLRs within a family recognize a general class of pathogen-associated molecular patterns. Most vertebrates have exactly one gene ortholog for each TLR family. The family including TLR1 has more species-specific adaptations than other families. A major family including TLR11 is represented in humans only by a pseudogene. Coincidental evolution plays a minor role in TLR evolution. The sequencing phase of this study produced finished genomic sequences for the 12 Takifugu rubripes TLRs. In addition, we have produced > 70 gene models, including sequences from the opossum, chicken, frog, dog, sea urchin, and sea squirt.
机译：Takifugu Toll样受体（TLR）基因座的完整序列以及来自许多草图基因组的基因预测可进行全面的分子系统发育分析。识别和响应病原体相关分子模式的强大选择压力在所有脊椎动物中都保持了很大程度上不变的TLR识别。脊椎动物TLR有六个主要家族。该曲目与无脊椎动物不同。一个家庭中的TLR识别与病原体相关的分子模式的一般类别。大多数脊椎动物对于每个TLR家族都只有一个基因直系同源物。包括TLR1的科比其他科具有更多的物种特定适应性。包括TLR11在内的一个主要家族在人类中仅由假基因代表。巧合的进化在TLR进化中仅扮演次要角色。这项研究的测序阶段产生了12株T柳TLRs的完整基因组序列。此外，我们已经产生了70多个基因模型，包括负鼠，鸡，青蛙，狗，海胆和海鞘的序列。

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