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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The striatofugal fiber system in primates: A reevaluation of its organization based on single-axon tracing studies
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The striatofugal fiber system in primates: A reevaluation of its organization based on single-axon tracing studies

机译：灵长类动物的层状真菌纤维系统：基于单轴突跟踪研究对其组织的重新评估

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The current model of basal ganglia rests on the idea that the striatofugal system is composed of two separate (direct and indirect) pathways originating from distinct cell populations in the striatum. The striatum itself is divided into two major compartments, the striosomes and the matrix, which differ by their neurochemical makeup and input/output connections. Here, neurons located in either striosomes or the extrastriosomal matrix in squirrel monkeys were injected with biotin dextran amine, and their labeled axons were entirely reconstructed with a camera lucida. Twenty-four of 27 reconstructed axons arborized into the three main striatal targets (external pallidum, globus pallidus, and substantia nigra pars reticulata), a finding that is at odds with the concept of a dual striatofugal system. Axons of striosomal neurons formed several columnar terminal fields in the substantia nigra pars reticulata. These data indicate that the substantia nigra pars compacta is neither the only nor the main target of striosomal neurons, a finding that calls for a reevaluation of the organization of the striatonigral projection system.
机译：当前的基底神经节模型基于以下思想：纹状体-真菌系统由源自纹状体中不同细胞群体的两个分开的（直接和间接）途径组成。纹状体本身分为两个主要的区室，即脂质体和基质，它们的神经化学组成和输入/输出连接方式不同。在这里，对松鼠猴中位于质体或纹状体外基质中的神经元注射生物素葡聚糖胺，并用相机lucida完全重建其标记的轴突。 27个重建轴突中有24个被乔装成三个主要纹状体靶标（外部苍白球，苍白球和黑质网状），这一发现与双重纹状体-真菌系统的概念不一致。纹状体神经元的轴突在黑质网状组织中形成了几个柱状末端区域。这些数据表明黑质致密部既不是纹状体神经元的唯一靶标，也不是其主要靶标，这一发现要求重新评估纹状体-神经投射系统的组织。

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