Low-frequency normal mode in DNA HhaI methyltransferase and motions of residues involved in the base flipping.

Luo J; Bruice TC

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Low-frequency normal mode in DNA HhaI methyltransferase and motions of residues involved in the base flipping.

机译：DNA HhaI甲基转移酶的低频正常模式和参与碱基翻转的残基运动。

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摘要

The results of normal-mode analyses are in accord with the proposal that a low-frequency motion of the HhaI methyltransferase enzyme is responsible for base flipping in bound DNA. The vectors of the low-frequency normal mode of residues Ser-85 and Ile-86 point directly to the phosphate and ribose moieties of the DNA backbone near the target base in position to rotate the dihedral angles and flip the base out of the DNA duplex. The vector of residue Gln-237 on the major groove is in the proper orientation to assist base separation. Our results favor the major groove pathway and the protein active process in base flipping.

机译：正常模式分析的结果与HhaI甲基转移酶的低频运动负责结合的DNA中的碱基翻转有关。低频正常模式残基Ser-85和Ile-86的载体直接指向目标碱基附近的DNA骨架的磷酸和核糖部分，从而旋转二面角并使碱基从DNA双链体中翻转出来。。主凹槽上的残基Gln-237的向量处于正确的方向，以帮助碱基分离。我们的结果支持碱基翻转中的主要沟途径和蛋白质活性过程。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2005年第45期|P.16194-16198|共5页
作者
Luo J; Bruice TC;
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作者单位

Department of Chemistry and Biology, University of California, Santa Barbara, CA 93106.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Base; NOS; DNA; With frequency; Methyltransferases; Low; 甲基转移酶类;

机译：Base;NOS;DNA;With frequency;Methyltransferases;Low;甲基转移酶类;

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2. Residues distal from the active site that alter enzyme function in M.HhaI DNA cytosine methyltransferase. [J] . Sharma V, Youngblood B, Reich N Journal of Biomolecular Structure and Dynamics . 2005,第5期

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3. Interaction of the type I methyltransferase M.EcoR124I with modified DNA substrates: sequence discrimination and base flipping. [J] . Mernagh DR, Taylor IA, Kneale GG The Biochemical Journal . 1998,第Pta3期

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5. Developing DNA probes to trap DNA cytosine-5 methyltransferases involved in promoter hypermethylation in cancer. [D] . Shigdel, Uddhav Kumar. 2009

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6. Low-frequency normal mode in DNA HhaI methyltransferase and motions of residues involved in the base flipping [O] . Jia Luo, Thomas C. Bruice 2005

机译：DNA HhaI甲基转移酶的低频正常模式和碱基翻转涉及的残基运动
7. Low-frequency normal mode in DNA HhaI methyltransferase and motions of residues involved in the base flipping [O] . Luo, Jia, Bruice, Thomas C. 2005

机译：DNA HhaI甲基转移酶的低频正常模式和碱基翻转涉及的残基运动

Low-frequency normal mode in DNA HhaI methyltransferase and motions of residues involved in the base flipping.

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