Inferring the in vivo looping properties of DNA.

Saiz L; Rubi JM; Vilar JM

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Inferring the in vivo looping properties of DNA.

机译：推断DNA的体内环化性质。

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摘要

The free energy of looping DNA by proteins and protein complexes determines to what extent distal DNA sites can affect each other. We inferred its in vivo value through a combined computational-experimental approach for different lengths of the loop and found that, in addition to the intrinsic periodicity of the DNA double helix, the free energy has an oscillatory component of about half the helical period. Moreover, the oscillations have such an amplitude that the effects of regulatory molecules become strongly dependent on their precise DNA positioning and yet easily tunable by their cooperative interactions. These unexpected results can confer to the physical properties of DNA a more prominent role at shaping the properties of gene regulation than previously thought.

机译：蛋白质和蛋白质复合物环化DNA的自由能决定了远端DNA位点可以互相影响的程度。我们通过组合的计算-实验方法针对不同的环长度推断出其体内值，发现除了DNA双螺旋的固有周期外，自由能的振荡成分约为螺旋周期的一半。而且，振荡具有这样的幅度，使得调节分子的作用变得强烈地依赖于其精确的DNA定位，并且易于通过其协同相互作用进行调节。这些出乎意料的结果可以赋予DNA物理特性比以前认为的更重要的作用，以决定基因调控的特性。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2005年第49期|P.17642-17645|共4页
作者
Saiz L; Rubi JM; Vilar JM;
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作者单位

Integrative Biological Modeling Laboratory, Computational Biology Program, Memorial Sloan-Kettering Cancer Center, 307 East 63rd Street, New York, NY 10021, USA.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
DNA; in vivo; free energy; Proteins; experiment; 蛋白质类;

机译：DNA;in vivo;free energy;Proteins;experiment;蛋白质类;

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6. Inferring the in vivo looping properties of DNA [O] . Leonor Saiz, J. Miguel Rubi, Jose M. G. Vilar 2005

机译：推断DNA的体内环化性质
7. Inferring the in vivo looping properties of DNA [O] . Saiz, Leonor, Rubi, J. Miguel, Vilar, Jose M. G. 2005

机译：推断DNA的体内环化性质

Inferring the in vivo looping properties of DNA.

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