...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >An analysis of the gene expression program of mammalian neural progenitor cells
【24h】

An analysis of the gene expression program of mammalian neural progenitor cells

机译：哺乳动物神经祖细胞的基因表达程序分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A diverse range of neural cell types is generated from a pool of dividing stem and progenitor cells in an orderly manner during development. Little is known of the molecular and cellular biology underpinning the intrinsic control of this process. We have used a nonbiased method to purify populations of neural progenitor cells from the murine CNS to characterize the gene expression program of mammalian retinal progenitor cells. Analysis of these data led to the identification of a core set of >800 transcripts enriched in retinal progenitor cells compared to both their immediate postmi-totic progeny and to differentiated neurons. This core set was found to be shared by progenitors in other regions of the developing CNS, with important regional differences in key functional families. In addition to providing an expression fingerprint of this cell type, this set highlights several key aspects of progenitor biology.
机译：在发育过程中，从分裂的干细胞和祖细胞池中有序地产生了多种神经细胞类型。分子和细胞生物学支持这一过程的内在控制知之甚少。我们已经使用一种无​​偏方法从鼠CNS纯化神经祖细胞群，以表征哺乳动物视网膜祖细胞的基因表达程序。对这些数据的分析导致鉴定出了一组富含800种转录本的核心转录本，与它们的直接放射后代和分化的神经元相比，它们富含视网膜祖细胞。发现该核心集由发展中的中枢神经系统其他区域的祖细胞共享，在关键功能家族中存在重要的区域差异。除了提供这种细胞类型的表达指纹外，该集还突出了祖细胞生物学的几个关键方面。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号