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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Timing of brain-derived neurotrophic factor exposure affects life expectancy of new neurons
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Timing of brain-derived neurotrophic factor exposure affects life expectancy of new neurons

机译：脑源性神经营养因子暴露的时间影响新神经元的预期寿命

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摘要

The high vocal center (HVC) of adult male canaries, Serinus canaria, is necessary for the production of learned song. New neurons are added to HVC every day, where they replace older neurons that have died, but the length of their survival depends on the time of year when they are born. A great number of HVC neurons born in the fall, when adult canaries learn a new song, are still present 8 mo later, when this song is used during the breeding season. By contrast, most of the neurons born in HVC in the spring, when little song learning takes place, disappear much sooner. Here we show that infusion of brain-derived neurotrophic factor into HVC during days 14-20 after new HVC neurons are born in the spring confers on them a life expectancy comparable to that of fall-born neurons; this extension on life is not seen when infusion occurs 10 days earlier or later. We suggest that there is, in the adult HVC, a subset of neurons whose life expectancy is determined by brain-derived neurotrophic factor during a sensitive period soon after these neurons reach destination and start forming connections. [References: 27]
机译：成年雄性金丝雀（Serinus canaria）的高发声中心（HVC）是生产学到的歌曲所必需的。每天都会将新的神经元添加到HVC中，在那里它们替换已经死亡的较旧的神经元，但是它们的存活时间取决于它们出生的年份。当成年金丝雀学习一首新歌时，秋天出生的许多HVC神经元仍会在8个月后出现（当在繁殖季节使用这首歌时）。相比之下，春季学习HVC时出生的大多数神经元，很少进行歌曲学习时，很快就会消失。在这里，我们表明在春季新出生的HVC神经元出生后的14至20天内，将脑源性神经营养因子输注到HVC中可使它们的寿命与秋天出生的神经元相当。当输注发生在10天或更晚时，这种寿命不会延长。我们建议，在成人HVC中，在这些神经元到达目的地并开始形成连接后的敏感期内，神经元的预期寿命由脑源性神经营养因子决定。 [参考：27]

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