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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets.
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Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets.

机译：IL-7受体在记忆T细胞上的选择性表达可识别早期CD40L依赖的不同CD8 +记忆T细胞亚群的产生。

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摘要

Several recent studies have demonstrated that T-helper cell-dependent events during the initial priming period are required for the generation of CD8(+) T cell-mediated protective immunity. The underlying mechanisms of this phenomenon have not yet been determined, mostly because of difficulties in studying memory T cells or their precursor populations at early stages during immune responses. We identified IL-7 receptor (CD127) surface expression as a marker for long-living memory T cells, most importantly allowing the distinction between memory and effector T cells early after in vivo priming. The combination of surface staining for CD127 and CD62L further separates between two functionally distinct memory cell subsets, which are similar (if not identical) to cell subsets recently described as central memory T cells (CD127(high) and CD62L(high)) and peripheral effector memory T cells (CD127(high) and CD62L(low)). Using this new tool of memory T cell analysis, we demonstrate that CD8(+) T cell priming in the absence of T cell help or CD40L specifically alters the generation of the effector memory T cell subset, which appears to be crucial for immediate memory responses and long-term maintenance of effective protective immunity. Our data reveal a unique strategy to obtain information about the quality of long-term protective immunity early during an immune response, a finding that may be applied in a variety of clinical settings, including the rapid monitoring of vaccination success.
机译：几项最新研究表明，在初始启动阶段，依赖T辅助细胞的事件是产生CD8（+）T细胞介导的保护性免疫所必需的。这种现象的潜在机制尚未确定，主要是因为在免疫反应的早期阶段难以研究记忆T细胞或其前体种群。我们将IL-7受体（CD127）表面表达鉴定为长效记忆T细胞的标志物，最重要的是，可以在体内引发后早期区分记忆T细胞和效应T细胞。 CD127和CD62L的表面染色的组合进一步在两个功能不同的记忆细胞亚群之间分离，这与最近被称为中央记忆T细胞（CD127（高）和CD62L（高））和外周的细胞亚群相似（如果不相同）效应记忆T细胞（CD127（高）和CD62L（低））。使用这种新的记忆T细胞分析工具，我们证明了在没有T细胞帮助或CD40L的情况下CD8（+）T细胞启动特异地改变了效应记忆T细胞亚群的产生，这对于立即记忆反应至关重要并长期保持有效的保护性免疫力。我们的数据揭示了一种独特的策略，可以在免疫应答过程中尽早获得有关长期保护性免疫质量的信息，这一发现可能适用于多种临床环境，包括对疫苗接种成功率的快速监测。

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