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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Secreted transforming growth factor β2 activates NF-κB, blocks apoptosis, and is essential for the survival of some tumor cells
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Secreted transforming growth factor β2 activates NF-κB, blocks apoptosis, and is essential for the survival of some tumor cells

机译：分泌的转化生长因子β2激活NF-κB，阻断细胞凋亡，对于某些肿瘤细胞的生存至关重要

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摘要

The basis of constitutive activation of NF-κB, essential for survival and resistance to apoptosis in many tumors, is not well understood. We find that transforming growth factor β2 (TGFβ2), predominantly in its latent form, is secreted by several different types of tumor cell lines that exhibit constitutively active NF-κB and that TGFβ2 potently stimulates the activation of NF-κB in reporter cells. Suppression of TGFβ2 expression by small interfering RNA kills prostate cancer PC3 cells, indicating that the TGFβ2-NF-κB pathway is important for their viability. These findings identify TGFβ2 as a potential target for therapeutic strategies to inhibit the growth of tumor cells that depend on constitutively active NF-κB, or to sensitize them to treatment with cytotoxic drugs.
机译：NF-κB的组成性激活对于许多肿瘤的存活和抗凋亡至关重要，其基础尚不清楚。我们发现转化生长因子β2（TGFβ2）主要以其潜在形式被几种不同类型的肿瘤细胞系分泌，这些细胞系表现出组成性活性NF-κB，并且TGFβ2有力地刺激了报告细胞中NF-κB的激活。小干扰RNA抑制TGFβ2表达可杀死前列腺癌PC3细胞，这表明TGFβ2-NF-κB通路对其生存能力很重要。这些发现确定TGFβ2是抑制依赖组成型活性NF-κB的肿瘤细胞生长或使其对细胞毒性药物敏感的治疗策略的潜在靶标。

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