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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Connecting genes to metabolites by a systems biology approach
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Connecting genes to metabolites by a systems biology approach

机译：通过系统生物学方法将基因连接到代谢物

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Plants are of pivotal importance to sustain life on Earth because they supply oxygen, food, energy, and many valuable metabolites. All plant constituents, including secondary metabolites, some of which are used as flavors, fragrances, colorants, or pharma-ceuticals, are ultimately derived from primary products of photosynthesis through multiple enzymatic steps encoded by the genome of each plant. However, our knowledge of how both primary and secondary metabolites are synthesized and which genes are involved is far from complete. A better understanding of metabolite synthesis and the regulation thereof will be increasingly important for improving the sustainability and efficiency of useful plant production. Recently, the availability of entire genome sequences of Arabidopsis thaliana and rice and the development of functional genomics tools have allowed the elucidation of metabolite syntheses by a systems biology approach . The mining and exploitation of the data obtained from genomics and the related research areas of genomewide transcriptomics, proteomics, and metabo-lomics will bring us into a new era of understanding of biological systems (Fig. 1).
机译：植物对维持地球生命至关重要，因为它们提供氧气，食物，能量和许多有价值的代谢产物。所有植物成分，包括次生代谢产物，其中一些用作香料，香精，着色剂或药物，最终都通过每种植物基因组编码的多个酶促步骤，从光合作用的初级产物中衍生出来。但是，我们对初级和次级代谢物如何合成以及涉及哪些基因的知识还远远不够。更好地理解代谢产物的合成及其调控对于提高有用植物生产的可持续性和效率将变得越来越重要。最近，拟南芥和水稻的全基因组序列的可获得性以及功能基因组学工具的发展已允许通过系统生物学方法阐明代谢产物的合成。从基因组学以及全基因组转录组学，蛋白质组学和代谢组学的相关研究领域获得的数据的挖掘和开发将使我们进入对生物系统的新认识时代（图1）。

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