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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Methicillin-resistant Staphylococcus aureus in hospitals and the community: stealth dynamics and control catastrophes.
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Methicillin-resistant Staphylococcus aureus in hospitals and the community: stealth dynamics and control catastrophes.

机译：医院和社区的耐甲氧西林金黄色葡萄球菌：隐身动态和控制灾难。

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摘要

Methicillin-resistant Staphylococcus aureus (MRSA) represents a serious threat to the health of hospitalized patients. Attempts to reduce the spread of MRSA have largely depended on hospital hygiene and patient isolation. These measures have met with mixed success: although some countries have almost eliminated MRSA or remained largely free of the organism, others have seen substantial increases despite rigorous control policies. We use a mathematical model to show how these increases can be explained by considering both hospital and community reservoirs of MRSA colonization. We show how the timing of the intervention, the level of resource provision, and chance combine to determine whether control measures succeed or fail. We find that even control measures able to repeatedly prevent sustained outbreaks in the short-term can result in long-term control failure resulting from gradual increases in the community reservoir. If resources do not scale with MRSA prevalence, isolation policies can fail "catastrophically."
机译：耐甲氧西林金黄色葡萄球菌（MRSA）对住院患者的健康构成严重威胁。减少MRSA传播的尝试很大程度上取决于医院的卫生状况和患者隔离情况。这些措施取得了不同程度的成功：尽管一些国家已几乎消除了MRSA或基本上没有这种生物，但尽管实行了严格的控制政策，其他国家却大幅度增加。我们使用数学模型来说明如何通过考虑MRSA定植的医院和社区水库来解释这些增加。我们展示了干预的时间安排，资源提供的水平以及机会如何确定控制措施是成功还是失败。我们发现，即使是能够在短期内反复预防持续爆发的控制措施，也可能由于社区水库逐渐增加而导致长期控制失败。如果资源不能随着MRSA的普及而扩展，隔离策略可能会“灾难性地”失败。

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