...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Treating cocaine addiction with viruses.
【24h】

Treating cocaine addiction with viruses.

机译：用病毒治疗可卡因成瘾。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cocaine addiction continues to be a major health and social problem in the United States and other countries. Currently used pharmacological agents for treating cocaine abuse have proved inadequate, leaving few treatment options. An alternative is to use protein-based therapeutics that can eliminate the load of cocaine, thereby attenuating its effects. This approach is especially attractive because the therapeutic agents exert no pharmacodynamic action of their own and therefore have little potential for side effects. The effectiveness of these agents, however, is limited by their inability to act directly within the CNS. Bacteriophage have the capacity to penetrate the CNS when administered intranasally. Here, a method is presented for engineering filamentous bacteriophage to display cocaine-binding proteins on its surface that sequester cocaine in the brain. These antibody-displaying constructs were examined by using a locomotor activity rodent model to assess the ability of the phage-displayed proteins to block the psychoactive effects of cocaine. Results presented demonstrate a strategy in the continuing efforts to find effective treatments for cocaine addiction and suggest the application of this protein-based treatment for other drug abuse syndromes.
机译：可卡因成瘾继续是美国和其他国家的主要健康和社会问题。事实证明，目前用于治疗可卡因滥用的药物不足，几乎没有治疗选择。一种替代方法是使用可消除可卡因负荷的蛋白疗法，从而减弱其作用。该方法特别有吸引力，因为治疗剂自身不发挥药效作用，因此几乎没有副作用。但是，这些代理的有效性受到其无法直接在CNS中起作用的限制。鼻内给药时，噬菌体具有穿透CNS的能力。在这里，提出了一种工程化丝状噬菌体的方法，以在其表面展示可卡因结合蛋白，从而将可卡因隔离在大脑中。通过使用运动活性啮齿动物模型检查了这些展示抗体的构建体，以评估噬菌体展示的蛋白阻断可卡因的精神活性的能力。提出的结果证明了在继续努力中寻找可卡因成瘾的有效疗法的策略，并提出了这种基于蛋白质的疗法在其他药物滥用综合症中的应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号