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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Interlocus nonrandom association of polymorphisms in Drosophila chemoreceptor genes
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Interlocus nonrandom association of polymorphisms in Drosophila chemoreceptor genes

机译：果蝇化学感受器基因多态性的位点间非随机关联

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Some forms of multilocus selection with epistasis, such as truncation selection, can effectively reduce the mutation load [Kondrashov, A. S. (1988) Nature 336, 435-440]. Many quantitative characters, including complex genetic diseases, are likely to be subject to these types of selection. However, direct measurement of selection in natural populations is difficult and the effect of epistasis on within-species variations remains unclear. Epistatic interaction in the fitness effect can generate linkage disequilibrium (LD). Therefore, we may detect the action of natural selection from its amount and pattern. Here, we report a large number of interlocus nonrandom associations between polymorphisms in 98 Drosophila chemoreceptor genes. LD was examined in two fly samples collected at the same location, but in different seasons. The amount of LD was much larger in the spring sample than in the autumn one. The between-sample difference was much more striking for the replacement polymorphisms than for the silent polymorphisms. This difference between the replacement and silent polymorphisms could not be attributed to differences in the mean marker distances. We also found a significant excess of associations between one frequent and one less common allele for the replacement polymorphisms, but not for the silent polymorphisms. It is unlikely that a simple seasonal bottleneck could explain all these differences in the scale of LD between the samples and between the replacement and silent polymorphisms. Natural selection is suggested to play a significant role in shaping the pattern of LD observed in this study.
机译：一些具有上位性的多基因座选择形式，例如截短选择，可以有效地降低突变负荷[Kondrashov，A.S。（1988）Nature 336，435-440]。许多定量特征，包括复杂的遗传疾病，都可能受到这些类型的选择。然而，直接测量自然种群中的选择是困难的，并且上位性对种内变异的影响仍然不清楚。适应性效应中的上位性相互作用会产生连锁不平衡（LD）。因此，我们可以从自然选择的数量和模式中检测其作用。在这里，我们报告了98个果蝇化学感受器基因多态性之间的大量位点间非随机关联。在相同位置但不同季节收集的两个果蝇样品中检查了LD。春季样品中的LD量比秋季样品中的LD量大得多。替换多态性的样本间差异比沉默多态性的样本间差异大得多。替换和沉默多态性之间的这种差异不能归因于平均标记距离的差异。我们还发现替换多态性在一个频繁的和一个不那么常见的等位基因之间有显着的关联，而对于沉默的多态性则没有。一个简单的季节性瓶颈不可能解释样品之间以及替代和沉默多态性之间的LD规模的所有这些差异。建议自然选择在塑造本研究中观察到的LD模式中起重要作用。

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