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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Regulatory potential and control of Foxp3 expression in newborn CD4(+) T cells
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Regulatory potential and control of Foxp3 expression in newborn CD4(+) T cells

机译：新生CD4（+）T细胞中Foxp3表达的调节潜力和控制。

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摘要

Thymectomy at day 3 after birth leads to autoimmune disease in some genetic backgrounds. Disease is thought to be caused by the lack/paucity of regulatory T cells. We show that 3-day-old mice already contain a significant compartment of Foxp3-expressing CD25(+)CD4(+) splenocytes. Whereas, in adult spleen, the subsets of regulatory T cells (CD25(+) and/or CD103(+)) express high amounts of Foxp3 mRNA, in 3-day-old mice, both thymic and splenic CD25(+)CD4(+) T cell subsets express lower amounts of Foxp3 mRNA, and CD103(+) cells are barely detected. In adult day 3-thymectomized mice, the CD25(+)CD4(+) T cell subset is overrepresented (most of the cells being CD103(+)) and expresses high amounts of Foxp3 mRNA, independent of the development of autoimmune gastritis. These cells control inflammatory bowel disease and the homeostatic expansion of lymphocytes. This study demonstrates that the peripheral immune system of newborn mice is endowed of a remarkable regulatory potential, which develops considerably in the absence of thymic supply.
机译：出生后第3天进行胸腺切除术会导致某些遗传背景下的自身免疫性疾病。疾病被认为是由于缺乏调节性T细胞引起的。我们显示3天大的小鼠已经包含Foxp3表达CD25（+）CD4（+）脾细胞的显着隔室。而在成年脾脏中，调节性T细胞的子集（CD25（+）和/或CD103（+））在3天大的小鼠中，胸腺和脾脏CD25（+）CD4（ +）T细胞亚群表达的Foxp3 mRNA含量较低，而CD103（+）细胞几乎没有被检测到。在成年3日经胸腺切除的小鼠中，CD25（+）CD4（+）T细胞亚群被过度代表（大多数细胞为CD103（+）），并表达高水平的Foxp3 mRNA，而与自身免疫性胃炎的发展无关。这些细胞控制炎症性肠病和淋巴细胞的稳态扩增。这项研究表明，新生小鼠的外周免疫系统具有显着的调节潜力，这种调节能力在没有胸腺供应的情况下会显着发展。

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