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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Complete genome sequence of Lactobacillus plantarum WCFS1.
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Complete genome sequence of Lactobacillus plantarum WCFS1.

机译：植物乳杆菌WCFS1的完整基因组序列。

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摘要

The 3,308,274-bp sequence of the chromosome of Lactobacillus plantarum strain WCFS1, a single colony isolate of strain NCIMB8826 that was originally isolated from human saliva, has been determined, and contains 3,052 predicted protein-encoding genes. Putative biological functions could be assigned to 2,120 (70%) of the predicted proteins. Consistent with the classification of L. plantarum as a facultative heterofermentative lactic acid bacterium, the genome encodes all enzymes required for the glycolysis and phosphoketolase pathways, all of which appear to belong to the class of potentially highly expressed genes in this organism, as was evident from the codon-adaptation index of individual genes. Moreover, L. plantarum encodes a large pyruvate-dissipating potential, leading to various end-products of fermentation. L. plantarum is a species that is encountered in many different environmental niches, and this flexible and adaptive behavior is reflected by the relatively large number of regulatory and transport functions, including 25 complete PTS sugar transport systems. Moreover, the chromosome encodes >200 extracellular proteins, many of which are predicted to be bound to the cell envelope. A large proportion of the genes encoding sugar transport and utilization, as well as genes encoding extracellular functions, appear to be clustered in a 600-kb region near the origin of replication. Many of these genes display deviation of nucleotide composition, consistent with a foreign origin. These findings suggest that these genes, which provide an important part of the interaction of L. plantarum with its environment, form a lifestyle adaptation region in the chromosome.
机译：已经确定了植物乳杆菌WCFS1的染色体序列的3,308,274-bp序列，该菌株最初是从人唾液中分离的NCIMB8826菌株的单菌落分离株，并包含3052个预测的蛋白质编码基因。推定的生物学功能可以分配给2120个预测蛋白（70％）。与植物乳杆菌分类为兼性异发酵乳酸菌一致，该基因组编码糖酵解和磷酸酮醇酶途径所需的所有酶，所有这些似乎都属于该生物中潜在高表达的基因类别。来自单个基因的密码子适应指数。此外，植物乳杆菌（L. plantarum）编码大量的丙酮酸消散潜力，导致发酵的各种最终产物。植物乳杆菌（L. plantarum）是在许多不同的环境生态环境中遇到的物种，这种灵活和适应的行为反映在相对大量的调节和运输功能上，包括25个完整的PTS糖运输系统。此外，该染色体编码> 200种细胞外蛋白，其中许多蛋白预计会与细胞包膜结合。编码糖运输和利用的大部分基因，以及编码细胞外功能的基因，似乎都聚集在复制起点附近的600 kb区域。这些基因中的许多显示核苷酸组成的偏差，与外来起源一致。这些发现表明，这些基因提供了植物乳杆菌与其环境相互作用的重要部分，在染色体上形成了一种生活方式适应区。

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