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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Modular organization of internal models of tools in the human cerebellum.
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Modular organization of internal models of tools in the human cerebellum.

机译：人类小脑中工具内部模型的模块化组织。

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摘要

Human capabilities in dexterously manipulating many different tools suggest modular neural organization at functional levels, but anatomical modularity underlying the capabilities has yet to be demonstrated. Although modularity in phylogenetically older parts of the cerebellum is well known, comparable modularity in the lateral cerebellum for cognitive functions remains unknown. We investigated these issues by functional MRI (fMRI) based on our previous findings of a cerebellar internal model of a tool. After subjects intensively learned to manipulate two novel tools (the rotated mouse whose cursor appeared at a rotated position, and the velocity mouse whose cursor velocity was proportional to the mouse position), they could easily switch between the two. The lateral and posterior cerebellar activities for the two different tools were spatially segregated, and their overlaps were <10%, even at low statistical thresholds. Activities of the rotated mouse were more anterior and lateral than the velocity mouse activities. These results were consistent with predictions by the MOdular Selection And Identification Controller (MOSAIC) model that multiple internal models compete to partition sensory-motor experiences and their outputs are linearly combined for a particular context.
机译：人类在灵巧地操纵许多不同工具方面的能力暗示了在功能水平上的模块化神经组织，但是该功能背后的解剖学模块化尚待证明。尽管小脑系统发育较老的部分中的模块性是众所周知的，但是对于认知功能而言，小脑外侧的可比模块性仍然未知。我们根据功能性小脑内部模型的先前发现，通过功能性MRI（fMRI）研究了这些问题。在受试者集中学习了两种新颖的工具（光标出现在旋转位置的旋转鼠标和光标速度与鼠标位置成比例的速度鼠标）后，他们可以轻松地在两者之间切换。两种不同工具的小脑外侧和后侧活动在空间上是分开的，即使在较低的统计阈值下，它们的重叠率也小于10％。旋转鼠标的活动比速度鼠标的活动更向前和向外侧。这些结果与模块选择和识别控制器（MOSAIC）模型的预测一致，即多个内部模型竞争分配感觉运动的经验，并且其输出针对特定情况进行线性组合。

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