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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Perturbations in B cell responsiveness to CD4~+ T cell help in HIV-infected individuals
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Perturbations in B cell responsiveness to CD4~+ T cell help in HIV-infected individuals

机译：B细胞对CD4〜+ T细胞反应性的扰动有助于HIV感染者

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摘要

HIV infection induces a wide array of B cell dysfunctions. We have characterized the effect of plasma viremia on the responsiveness of B cells to CD4~+ T cell help in HIV-infected patients. In HIV-negative donors, B cell proliferation correlated with CD154 expression on activated CD4~+ T cells and with the availability of IL-2, whereas in HIV-infected viremic patients, reduced B cell proliferation was observed despite normal CD154 expression on activated CD4~+ T cells. Reduced triggering of B cells by activated CD4~+ T cells was clearly observed in HIV-infected viremic patients compared with aviremic patients with comparable CD4~+ T cell counts, and a dramatic improvement in B cell function was observed in patients whose plasma viremia was controlled by effective antiretroviral therapy. The degree of B cell dysfunction in viremic patients correlated strongly with the inability of B cells to express CD25 in response to activated CD4~+ T cells, resulting in an inability to mount a normal proliferative response to IL-2. Similar defects in responsiveness to IL-2 were observed in the B cells of HIV-infected viremic patients in the context of B cell receptor stimulation. These data provide new insight into the mechanisms associated with ineffective humoral responses in HIV disease.
机译：HIV感染会引起多种B细胞功能障碍。我们已经表征了血浆病毒血症对HIV感染患者的B细胞对CD4〜+ T细胞帮助的反应性的影响。在HIV阴性供体中，B细胞增殖与活化的CD4〜+ T细胞上CD154表达和IL-2的可用性相关，而在HIV感染的病毒血症患者中，尽管活化的CD4上CD154表达正常，但观察到B细胞增殖减少。 〜+ T细胞。与具有可比的CD4〜+ T细胞计数的非航空患者相比，在HIV感染的病毒血症患者中，明显观察到活化的CD4〜+ T细胞对B细胞的触发作用减少，并且血浆病毒血症为50％的患者的B细胞功能显着改善。通过有效的抗逆转录病毒疗法控制。在病毒血症患者中，B细胞功能障碍的程度与B细胞无法表达CD25响应活化的CD4 + T细胞有关，从而导致无法对IL-2产生正常的增殖反应。在B细胞受体刺激的情况下，在HIV感染的病毒血症患者的B细胞中观察到了对IL-2的类似反应缺陷。这些数据为与HIV疾病无效的体液反应相关的机制提供了新的见解。

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