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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Monocyte chemoattractant protein 1 in obesity and insulin resistance
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Monocyte chemoattractant protein 1 in obesity and insulin resistance

机译：肥胖与胰岛素抵抗中的单核细胞趋化蛋白1

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This study identifies monocyte chemoattractant protein 1 (MCP-1) as an insulin-responsive gene. It also shows that insulin induces substantial expression and secretion of MCP-1 both in vitro in insulin-resistant (111) 3T3-L1 adipocytes and in vivo in IR obese mice (ob/ob). Thus, MCPA resembles other previously described genes (e.g., PAI-1 and SREBP-1c) that remain sensitive to insulin in IR states. The hyperinsulinemia that frequently accompanies obesity and insulin resistance may therefore contribute to the altered expression of these and other genes in insulin target tissues. In vivo studies also demonstrate that MCP-1 is overexpressed in obese mice compared with their lean controls, and that white adipose tissue is a major source of MCP-1. The elevated MCP-1 may alter adipocyte function because addition of MCP-1 to differentiated adipocytes in vitro decreases insulin-stimulated glucose uptake and the expression of several adipogenic genes (LpL, adipsin, GLUT-4, aP2, beta3-adrenergic receptor, and peroxisome proliferator-activated receptor gamma). These results suggest that elevated MCP-1 may induce adipocyte dedifferentiation and contribute to pathologies associated with hyperinsulinemia and obesity, including type II diabetes. [References: 34]
机译：这项研究确定单核细胞趋化蛋白1（MCP-1）作为胰岛素反应基因。它还显示胰岛素在胰岛素抵抗（111）3T3-L1脂肪细胞中体外和在IR肥胖小鼠（ob / ob）体内均可诱导MCP-1的大量表达和分泌。因此，MCPA类似于其他先前描述的基因（例如，PAI-1和SREBP-1c），其在IR状态下仍对胰岛素敏感。因此，肥胖和胰岛素抵抗常伴有的高胰岛素血症可能会导致这些和其他基因在胰岛素靶组织中的表达改变。体内研究还表明，与瘦对照组相比，肥胖小鼠中MCP-1过表达，而白色脂肪组织是MCP-1的主要来源。升高的MCP-1可能会改变脂肪细胞的功能，因为在体外向分化的脂肪细胞中添加MCP-1会降低胰岛素刺激的葡萄糖摄取以及几种脂肪形成基因（LpL，脂肪蛋白，GLUT-4，aP2，β3-肾上腺素能受体和过氧化物酶体增殖物激活受体γ）。这些结果表明，升高的MCP-1可能诱导脂肪细胞去分化，并导致与高胰岛素血症和肥胖症（包括II型糖尿病）相关的病理。 [参考：34]

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