...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates
【24h】

Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates

机译：HIV-1感染中的自然杀伤细胞：病毒血症对抑制和激活受体及其功能相关性的二分作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Natural killer (NK) cells play a central role in host defense against various pathogens. Functional defects of NK cells in HIV-1 infection as a direct effect of abnormal expression or function of inhibitory NK receptors (iNKRs), activating natural cytotoxicity receptors (NCRs), and NKG2D have not yet been described. This study demonstrates an expansion of the functionally defective CD56~-/CD16~+ population of NK cells in viremic versus aviremic patients. We also demonstrate that in HIV-infected viremic patients, expression of iNKRs was well conserved and that in most cases, there was a trend toward increased expression on NK cells as compared with healthy donors. It was also demonstrated that the major activating NK receptors, with the exception of NKG2D, were significantly down-regulated. In contrast, the expression of iNKRs and activating receptors in HIV-infected individuals whose viremia was suppressed to below detectable levels by highly active antiretroviral therapy for 2 years or longer was comparable to that of healthy donors. Functional tests confirmed that the abnormal expression of the activating receptors and of iNKRs was associated with a markedly impaired NK cytolytic function. This phenomenon is not attributed to a direct HIV-1 infection of NK cells; thus, this study may provide insight into the mechanisms of impaired host defenses in HIV-1 viremic patients.
机译：天然杀伤（NK）细胞在宿主防御各种病原体的过程中起着核心作用。尚未描述HIV-1感染中NK细胞功能异常，抑制性NK受体（iNKR）异常表达或功能，激活天然细胞毒性受体（NCR）和NKG2D的直接作用。这项研究表明，在病毒血症和非病毒血症患者中，NK细胞功能缺陷的CD56〜-/ CD16〜+群体的扩增。我们还证明，在HIV感染的病毒血症患者中，iNKRs的表达得到了很好的保守，并且在大多数情况下，与健康供体相比，NK细胞上的表达有增加的趋势。还表明，除了NKG2D外，主要的激活性NK受体均被显着下调。相反，通过高效抗逆转录病毒疗法治疗2年或更长时间，其病毒血症被抑制到低于可检测水平的HIV感染者中，iNKRs和激活受体的表达与健康捐献者相当。功能测试证实，激活受体和iNKR的异常表达与NK细胞溶解功能明显受损有关。这种现象并非归因于NK细胞的HIV-1直接感染。因此，这项研究可能为洞悉HIV-1病毒血症患者宿主防御能力受损的机制提供了见识。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号