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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Potentiation of serum response factor activity by a family of myocardin-related transcription factors
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Potentiation of serum response factor activity by a family of myocardin-related transcription factors

机译：心肌相关转录因子家族增强血清反应因子活性

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摘要

Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two myocardin-related transcription factors (MRTFs), A and B, that also interact with SRF and stimulate its transcriptional activity. Whereas myocardin is expressed specifically in cardiac and smooth muscle cells, MRTF-A and -B are expressed in numerous embryonic and adult tissues. In SRF-deficient embryonic stem cells, myocardin and MRTFs are unable to activate SRF-dependent reporter genes, confirming their dependence on SRF. Myocardin and MRTFs comprise a previously uncharacterized family of SRF cofactors with the potential to modulate SRF target genes in a wide range of tissues.
机译：心肌素是一种SAP（SAF-A / B，Acinus，PIAS）域转录因子，可与血清反应因子（SRF）结合以有效增强SRF依赖性转录。在这里，我们描述了两个心肌相关转录因子（MRTFs）A和B，它们也与SRF相互作用并刺激其转录活性。心肌素在心脏和平滑肌细胞中特异性表达，而MRTF-A和-B在许多胚胎和成年组织中表达。在缺乏SRF的胚胎干细胞中，心肌素和MRTF无法激活SRF依赖的报告基因，从而证实了它们对SRF的依赖。心肌素和MRTFs包含一个以前未鉴定的SRF辅助因子家族，具有调节多种组织中SRF靶基因的潜力。

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