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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis
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A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis

机译：纤连蛋白片段抑制肿瘤生长，血管生成和转移

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We have shown previously that a polymeric form of fibronectin is strongly antimetastatic when administered systemically to tumor- bearing mice. The polymeric fibronectin, sFN, is formed in vitro by treating soluble fibronectin with a 76-aa peptide, Ⅲ1-C, which is derived from the first type Ⅲ repeat in fibronectin. Here we show that the Ⅲ1-C peptide and sFN also reduce tumor growth in mice, and that this effect correlates with a low density of blood vessels in the tumors of the treated mice. Ⅲ1-C also polymerized fibrino- gen. and the fibrinogen polymer, sFBG. had antitumor and anti- angiogenic effects similar to those of sFN. Mice that had been injected s.c. with three different types of human tumor cells and treated with biweekly i.p. injections of Ⅲ1-C. sFN, or sFBG over a 5-week period had tumors that were 50-90/100 smaller than those of control mice. Blood vessel density in the tumors of the treated mice was reduced by 60-80/100 at the end of the experiment. Xenograft tumors from a human breast carcinoma line (MDA-MB- 435) were particularly susceptible to these treatments. Metastasis into the lungs from the primary s.c. tumors also was inhibited in the mice treated with Ⅲ1-C and the two polymers. The Ⅲ1-C peptide is an antiangiogenic and antimetastatic agent. Because of its ability to suppress tumor growth, angiogenesis, and metastasis, we have named the Ⅲ1-C peptide anastellin [from anastello (Greek), inhibit, force a retreat].
机译：先前我们已经表明，当全身给药于荷瘤小鼠时，纤连蛋白的聚合形式具有强烈的抗转移性。聚合物纤连蛋白sFN是在体外用76-aa肽Ⅲ1-C处理可溶性纤连蛋白而形成的，该肽源自纤连蛋白的第一个Ⅲ型重复序列。在这里，我们证明了Ⅲ1-C肽和sFN也降低了小鼠的肿瘤生长，并且这种作用与所治疗小鼠的肿瘤中血管密度低有关。 Ⅲ1-C也聚合了纤维蛋白原。以及纤维蛋白原聚合物sFBG。具有与sFN相似的抗肿瘤和抗血管生成作用。皮下注射的小鼠用三种不同类型的人类肿瘤细胞治疗，并每两周一次腹膜内注射。注射Ⅲ1-C。在5周内，sFN或sFBG的肿瘤比对照小鼠小50-90 / 100。在实验结束时，治疗小鼠的肿瘤中的血管密度降低了60-80 / 100。来自人乳腺癌细胞系（MDA-MB-435）的异种移植肿瘤特别容易受到这些治疗的影响。从原发癌转移到肺部用Ⅲ1-C和两种聚合物治疗的小鼠肿瘤也被抑制。 Ⅲ1-C肽是一种抗血管生成和抗转移剂。由于其具有抑制肿瘤生长，血管生成和转移的能力，我们将Ⅲ1-C肽anastellin命名为[来自anastello（Greek），抑制并强迫撤退]。

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